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ALKBH2 cdna clone

Scan QR to view Datasheet Catalog #    MBS1271596 ALKBH2 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALKBH2, cDNA Clone

 Also Known As   

ALKBH2 cDNA Clone

 Product Gene Name   

ALKBH2 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggacagat tcctggtgaa aggggctcaa gggggccttt tgaggaagca ggaggagcaa gagccaactg gagaagagcc agctgtgttg ggaggagaca aagaaagcac aaggaagagg cccaggagag aggccccagg gaatggaggc cactcagcag gccctagctg gcggcacatt cgggctgagg gcctggactg cagttacaca gtcctgtttg gcaaagctga ggcagatgag attttccaag agttggagaa agaagtagaa tattttacag gagcactggc cagagtccag gtattcggga agtggcacag tgtgcccagg aagcaggcaa cgtatggcga cgctgggctg acctacacat tttcaggcct cacgctgtct ccaaagccct ggatcccagt tctagagcgc atccgggatc acgtctctgg ggtgactgga cagaccttca actttgtgct catcaacagg tataaagatg gctgtgacca catcggggag caccgagatg atgaaagaga actggcccct gggagcccca ttgcctctgt ctccttcggt gcctgcagag actttgtctt ccggcataag gattcccgtg ggaaaagccc ctccaggagg gtggcggtgg tcaggctgcc gctggcccac gggagcttac taatgatgaa ccacccgacc aacacgcact ggtaccacag tcttcccgtg agaaagaagg ttctggctcc acgggtgaat ctgacttttc gtaaaatttt gcttactaaa aaataa
 OMIM    610602
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ALKBH2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ALKBH2. It may not necessarily be applicable to this product.
 NCBI GI #    47124095
 NCBI GeneID    121642
 NCBI Accession #    BC070489 [Other Products]
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 UniProt Secondary Accession #    Q5XLE3; A4PET2 [Other Products]
 UniProt Related Accession #    Q6NS38 [Other Products]
 Molecular Weight    17,083 Da
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 NCBI Official Full Name    Homo sapiens alkB, alkylation repair homolog 2 (E. coli), mRNA
 NCBI Official Synonym Full Names    alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
 NCBI Official Symbol    ALKBH2 [Similar Products]
 NCBI Official Synonym Symbols   
ABH2
[Similar Products]
 NCBI Protein Information    DNA oxidative demethylase ALKBH2
 UniProt Protein Name    DNA oxidative demethylase ALKBH2
 UniProt Synonym Protein Names   
Alkylated DNA repair protein alkB homolog 2; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; Oxy DC1
 Protein Family    DNA oxidative demethylase
 UniProt Gene Name    ALKBH2 [Similar Products]
 UniProt Synonym Gene Names    ABH2 [Similar Products]
 UniProt Entry Name    ALKB2_HUMAN
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 NCBI Summary for ALKBH2    The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for ALKBH2    ALKBH2: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; EC 1.14.11.33; Demethylase; DNA repair, damage; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus

Molecular Function: DNA demethylase activity; DNA-N1-methyladenine dioxygenase activity; ferrous iron binding

Biological Process: DNA dealkylation
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 Research Articles on ALKBH2    1. studies reveal the ALKBH2 binding interface of PCNA and indicate that both germline and somatic ALKBH2 variants could have cellular effects on ALKBH2 function in DNA repair.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ALKBH2 cdna cloneDiseases associated with ALKBH2 cdna clone
 Products by Pathway  Pathway Diagram
 ABH2 Mediated Reversal Of Alkylation Damage Pathway antibodies  ABH2 Mediated Reversal Of Alkylation Damage Pathway Diagram
 DNA Damage Reversal Pathway antibodies  DNA Damage Reversal Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Reversal Of Alkylation Damage By DNA Dioxygenases Pathway antibodies  Reversal Of Alkylation Damage By DNA Dioxygenases Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with ALKBH2 and Neoplasms
 Inflammation Antibodies  >2 publications with ALKBH2 and Inflammation
 Lung Neoplasms Antibodies  >1 publications with ALKBH2 and Lung Neoplasms
 Nervous System Diseases Antibodies  >1 publications with ALKBH2 and Nervous System Diseases
Organs/Tissues associated with ALKBH2 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with ALKBH2 and Brain
 Pancreas Antibodies  >1 publications with ALKBH2 and Pancreas
 Intestine Antibodies  >1 publications with ALKBH2 and Intestine
 Stomach Antibodies  >1 publications with ALKBH2 and Stomach
 Lung Antibodies  >1 publications with ALKBH2 and Lung
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