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APOBEC3G cdna clone

Scan QR to view Datasheet Catalog #    MBS1278959 APOBEC3G cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


★Popular Item★
 Also Known As   


 Product Gene Name   

APOBEC3G cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgaagcctc acttcagaaa cacagtggag cgaatgtatc gagacacatt ctcctacaac ttttataata gacccatcct ttctcgtcgg aataccgtct ggctgtgcta cgaagtgaaa acaaagggtc cctcaaggcc ccctttggac gcaaagatct ttcgaggcca ggtaccaccc ggactccaat cactttgcag gcaggagcta agccagctgg gaaagcaaac cacgcactga
 OMIM    607113
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of APOBEC3G cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for APOBEC3G. It may not necessarily be applicable to this product.
 NCBI GI #    38303910
 NCBI GeneID    60489
 NCBI Accession #    BC061914 [Other Products]
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 UniProt Secondary Accession #    Q45F02; Q5TF77; Q7Z2N1; Q7Z2N4; Q9H9H8; B2RDR9 [Other Products]
 UniProt Related Accession #    Q9HC16 [Other Products]
 Molecular Weight    9,386 Da
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 NCBI Official Full Name    Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G, mRNA
 NCBI Official Synonym Full Names    apolipoprotein B mRNA editing enzyme catalytic subunit 3G
 NCBI Official Symbol    APOBEC3G [Similar Products]
 NCBI Official Synonym Symbols   
A3G; ARCD; ARP9; ARP-9; CEM15; CEM-15; MDS019; bK150C2.7; dJ494G10.1
[Similar Products]
 NCBI Protein Information    DNA dC->dU-editing enzyme APOBEC-3G
 UniProt Protein Name    DNA dC->dU-editing enzyme APOBEC-3G
 UniProt Synonym Protein Names   
APOBEC-related cytidine deaminase; APOBEC-related protein; ARCD; APOBEC-related protein 9; ARP-9; CEM-15; CEM15; Deoxycytidine deaminase; A3G
 Protein Family    DNA dC->dU-editing enzyme
 UniProt Gene Name    APOBEC3G [Similar Products]
 UniProt Synonym Gene Names    APOBEC-related protein; ARCD; ARP-9; CEM15; A3G [Similar Products]
 UniProt Entry Name    ABC3G_HUMAN
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 NCBI Summary for APOBEC3G    This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for APOBEC3G    APOBEC3G: DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. May also prevent the transposition of a subset of retroelements. Binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing. Belongs to the cytidine and deoxycytidylate deaminase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing; Hydrolase; EC 3.5.4.-; RNA-binding

Chromosomal Location of Human Ortholog: 22q13.1-q13.2

Cellular Component: apolipoprotein B mRNA editing enzyme complex; cytoplasm; cytosol; ribonucleoprotein complex

Molecular Function: cytidine deaminase activity; dCTP deaminase activity; deoxycytidine deaminase activity; protein binding; RNA binding; zinc ion binding

Biological Process: base conversion or substitution editing; cytidine deamination; defense response to virus; innate immune response; negative regulation of retroviral genome replication; negative regulation of viral genome replication; negative regulation of viral reproduction; positive regulation of defense response to virus by host
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 Research Articles on APOBEC3G    1. results demonstrate that the up-regulation of A3G in pancreatic cancer cells induces anoikis resistance, and they provide novel insight into the mechanism by which A3G affects the malignant behavior of pancreatic cancer cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with APOBEC3G cdna cloneDiseases associated with APOBEC3G cdna clone
 Products by Pathway  Pathway Diagram
 APOBEC3G Mediated Resistance To HIV-1 Infection Pathway antibodies  APOBEC3G Mediated Resistance To HIV-1 Infection Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Vif-mediated Degradation Of APOBEC3G Pathway antibodies  Vif-mediated Degradation Of APOBEC3G Pathway Diagram
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >39 publications with APOBEC3G and Leukemia
 Neoplasms Antibodies  >22 publications with APOBEC3G and Neoplasms
 Necrosis Antibodies  >7 publications with APOBEC3G and Necrosis
 Disease Models, Animal Antibodies  >7 publications with APOBEC3G and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >6 publications with APOBEC3G and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >5 publications with APOBEC3G and Neoplasms, Experimental
 Kidney Diseases Antibodies  >3 publications with APOBEC3G and Kidney Diseases
 Prostatic Diseases Antibodies  >3 publications with APOBEC3G and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >2 publications with APOBEC3G and Prostatic Neoplasms
 Drug Toxicity Antibodies  >2 publications with APOBEC3G and Drug Toxicity
Organs/Tissues associated with APOBEC3G cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >157 publications with APOBEC3G and Blood
 Liver Antibodies  >18 publications with APOBEC3G and Liver
 Kidney Antibodies  >18 publications with APOBEC3G and Kidney
 Brain Antibodies  >7 publications with APOBEC3G and Brain
 Prostate Antibodies  >6 publications with APOBEC3G and Prostate
 Muscle Antibodies  >6 publications with APOBEC3G and Muscle
 Bone Marrow Antibodies  >4 publications with APOBEC3G and Bone Marrow
 Bone Antibodies  >4 publications with APOBEC3G and Bone
 Heart Antibodies  >3 publications with APOBEC3G and Heart
 Spleen Antibodies  >3 publications with APOBEC3G and Spleen
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