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ARHGEF10 cdna clone

Scan QR to view Datasheet Catalog #    MBS1268950 ARHGEF10 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARHGEF10, cDNA Clone

★Popular Item★
 Also Known As   


 Product Gene Name   

ARHGEF10 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggagaatc cagaagaagc aatttacgat gacgttccaa gggaaaactc agactctgaa ccagatgaaa tgatttatga tgatgttgag aatggggatg aaggtggaaa cagctccttg gaatacggat ggagttcgag tgaatttgaa agttacgaag agcagagtga ctcggagtgc aagaatggga ttcccaggtc cttcctgcgc agcaaccaca aaaagcaaat gcagaagctc gtgaaggccg cgaaggacgg caccaaggac gggctggaga ggaccagggc agccgtgaag aggggccgct ccttcatcag gaccaagtct ctcatcgcac aggatcacag atcttctctt gaggaagaac agaatttgtt cattgatgtt gactgcaagc acccggaagc catcttgacc ccgatgcccg agggtttatc tcagcagcag gttgtaagaa gatatatact gggttcagtt gtcgacagtg aaaagaacta cgtagatgct cttaagagga ttttggagca atatgagaag ccgctgtctg agatggagcc aaaggttctg agtgagagga agctgaagac ggtgttctac cgagtcaaag agatcctgca gtgccactcg ctatttcaga tcgcgctggc cagccgcgtt tccgagtggg actccgtgga aatgataggc gttgtcttcg tggcttcgtt ttctaagtcc atggtgctgg atgcatacag tgaatatgtg aacaatttca gcacagccgt ggcagtcctc aagaaaacat gtgccacaaa gcccgctttt cttgaatttt taaagcagga acaggaggcc agccccgatc gaaccacgct ctacagcctg atgatgaagc ccatccagag gttcccacag ttcatcctcc tgctccagga catgctgaag aacacctcca aaggccaccc cgacaggctg cctcttcaga tggccctgac agagctcgaa acactagcag agaagttaaa tgaaagaaag agagatgctg atcaacgctg tgaagtgaag caaatagcca aagccataaa cgaaagatac ctgaacaagg ttgagagagg ttttcttcaa ctctattcca aaattatttt tgctttgtgc taa
 OMIM    608136
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ARHGEF10 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ARHGEF10. It may not necessarily be applicable to this product.
 NCBI GI #    26251961
 NCBI GeneID    9639
 NCBI Accession #    BC040474 [Other Products]
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 UniProt Secondary Accession #    O14665; Q2KHR8; Q68D55; Q8IWD9; Q8IY77 [Other Products]
 UniProt Related Accession #    O15013 [Other Products]
 Molecular Weight    148,869 Da
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 NCBI Official Full Name    Homo sapiens Rho guanine nucleotide exchange factor (GEF) 10, mRNA
 NCBI Official Synonym Full Names    Rho guanine nucleotide exchange factor 10
 NCBI Official Symbol    ARHGEF10 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    rho guanine nucleotide exchange factor 10
 UniProt Protein Name    Rho guanine nucleotide exchange factor 10
 Protein Family    Rho guanine nucleotide exchange factor
 UniProt Gene Name    ARHGEF10 [Similar Products]
 UniProt Synonym Gene Names    KIAA0294 [Similar Products]
 UniProt Entry Name    ARHGA_HUMAN
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 NCBI Summary for ARHGEF10    This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
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 UniProt Comments for ARHGEF10    ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: centrosome

Molecular Function: kinesin binding; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: centrosome duplication; myelination in the peripheral nervous system; positive regulation of stress fiber formation

Disease: Slowed Nerve Conduction Velocity, Autosomal Dominant
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 Research Articles on ARHGEF10    1. Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ARHGEF10 cdna cloneDiseases associated with ARHGEF10 cdna clone
 Products by Pathway  Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with ARHGEF10 and Neoplasms
 Nervous System Diseases Antibodies  >4 publications with ARHGEF10 and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >3 publications with ARHGEF10 and Neurodegenerative Diseases
 Vascular Diseases Antibodies  >2 publications with ARHGEF10 and Vascular Diseases
 Brain Diseases Antibodies  >2 publications with ARHGEF10 and Brain Diseases
 Arteriosclerosis Antibodies  >1 publications with ARHGEF10 and Arteriosclerosis
 Liver Diseases Antibodies  >1 publications with ARHGEF10 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with ARHGEF10 and Liver Neoplasms
 Urinary Bladder Neoplasms Antibodies  >1 publications with ARHGEF10 and Urinary Bladder Neoplasms
Organs/Tissues associated with ARHGEF10 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >4 publications with ARHGEF10 and Nerve
 Brain Antibodies  >2 publications with ARHGEF10 and Brain
 Muscle Antibodies  >1 publications with ARHGEF10 and Muscle
 Liver Antibodies  >1 publications with ARHGEF10 and Liver
 Pancreas Antibodies  >1 publications with ARHGEF10 and Pancreas
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