BC104238
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,515 Da
NCBI Official Full Name
Homo sapiens agouti signaling protein, nonagouti homolog (mouse), mRNA
NCBI Official Synonym Full Names
agouti signaling protein
NCBI Protein Information
agouti-signaling protein
UniProt Protein Name
Agouti-signaling protein
UniProt Synonym Protein Names
Agouti switch protein
UniProt Synonym Gene Names
UniProt Entry Name
ASIP_HUMAN
NCBI Summary for ASIP
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
UniProt Comments for ASIP
ASIP: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 20q11.2-q12
Cellular Component: extracellular space
Molecular Function: receptor binding
Biological Process: cell-cell signaling; signal transduction
Disease: Skin/hair/eye Pigmentation, Variation In, 9
Research Articles on ASIP
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Pathways associated with ASIP cdna clone
Diseases associated with ASIP cdna clone
Organs/Tissues associated with ASIP cdna clone
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