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ASPA cdna clone

Scan QR to view Datasheet Catalog #    MBS1268608 ASPA cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ASPA, cDNA Clone

★Popular Item★
 Also Known As   


 Product Gene Name   

ASPA cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgacttctt gtcacattgc tgaagaacat atacaaaagg ttgctatctt tggaggaacc catgggaatg agctaaccgg agtatttctg gttaagcatt ggctagagaa tggcgctgag attcagagaa cagggctgga ggtaaaacca tttattacta accccagagc agtgaagaag tgtaccagat atattgactg tgacctgaat cgcatttttg accttgaaaa tcttggcaaa aaaatgtcag aagatttgcc atatgaagtg agaagggctc aagaaataaa tcatttattt ggtccaaaag acagtgaaga ttcctatgac attatttttg accttcacaa caccacctct aacatggggt gcactcttat tcttgaggat tccaggaata actttttaat tcagatgttt cattacatta agacttctct ggctccacta ccctgctacg tttatctgat tgagcatcct tccctcaaat atgcgaccac tcgttccata gccaagtatc ctgtgggtat agaagttggt cctcagcctc aaggggttct gagagctgat atcttggatc aaatgagaaa aatgattaaa catgctcttg attttataca tcatttcaat gaaggaaaag aatttcctcc ctgcgccatt gaggtctata aaattataga gaaagttgat tacccccggg atgaaaatgg agaaattgct gctatcatcc atcctaatct gcaggatcaa gactggaaac cactgcatcc tggggatccc atgtttttaa ctcttgatgg gaagacgatc ccactgggcg gagactgtac cgtgtacccc gtgtttgtga atgaggccgc atattacgaa aagaaagaag cttttgcaaa gacaactaaa ctaacgctca atgcaaaaag tattcgctgc tgtttacatt ag
 OMIM    271900
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ASPA cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ASPA. It may not necessarily be applicable to this product.
 NCBI GI #    20810517
 NCBI GeneID    443
 NCBI Accession #    BC029128 [Other Products]
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 UniProt Related Accession #    P45381 [Other Products]
 Molecular Weight    35,735 Da
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 NCBI Official Full Name    Homo sapiens aspartoacylase (Canavan disease), mRNA
 NCBI Official Synonym Full Names    aspartoacylase
 NCBI Official Symbol    ASPA [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    aspartoacylase
 UniProt Protein Name    Aspartoacylase
 UniProt Synonym Protein Names   
Aminoacylase-2; ACY-2
 Protein Family    Aspartocin
 UniProt Gene Name    ASPA [Similar Products]
 UniProt Synonym Gene Names    ACY2; ASP; ACY-2 [Similar Products]
 UniProt Entry Name    ACY2_HUMAN
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 NCBI Summary for ASPA    This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ASPA    ASPA: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids. Defects in ASPA are the cause of Canavan disease (CAND); also known as spongy degeneration of the brain. CAND is a rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average. Belongs to the AspA/AstE family. Aspartoacylase subfamily.

Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Cell development/differentiation; Hydrolase; EC; Amino Acid Metabolism - histidine

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cytoplasm; cytosol

Molecular Function: aminoacylase activity; aspartoacylase activity; protein binding

Biological Process: amino acid biosynthetic process; aspartate catabolic process

Disease: Canavan Disease
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 Research Articles on ASPA    1. report of 2 Egyptian sibling patients suspected of Canavan disease (CD); study revealed homozygosity for substitution T530C (Ile177Thr) in exon 4 of the ASPA gene in both sibs; substitution T530C (Ile177Thr) results in a novel missense mutation causing a CD phenotype with severe clinical characteristics
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ASPA cdna cloneDiseases associated with ASPA cdna clone
 Products by Pathway  Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Canavan Disease Antibodies  >64 publications with ASPA and Canavan Disease
 Nervous System Diseases Antibodies  >63 publications with ASPA and Nervous System Diseases
 Brain Diseases Antibodies  >57 publications with ASPA and Brain Diseases
 Neoplasms Antibodies  >13 publications with ASPA and Neoplasms
 Immune System Diseases Antibodies  >12 publications with ASPA and Immune System Diseases
 Drug Toxicity Antibodies  >10 publications with ASPA and Drug Toxicity
 Inflammation Antibodies  >8 publications with ASPA and Inflammation
 Seizures Antibodies  >8 publications with ASPA and Seizures
 Lymphatic Diseases Antibodies  >7 publications with ASPA and Lymphatic Diseases
 Nerve Degeneration Antibodies  >5 publications with ASPA and Nerve Degeneration
Organs/Tissues associated with ASPA cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >58 publications with ASPA and Brain
 Muscle Antibodies  >7 publications with ASPA and Muscle
 Kidney Antibodies  >5 publications with ASPA and Kidney
 Skin Antibodies  >2 publications with ASPA and Skin
 Ganglia Antibodies  >1 publications with ASPA and Ganglia
 Adrenal Gland Antibodies  >1 publications with ASPA and Adrenal Gland
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