BC008861
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,329 Da
NCBI Official Full Name
Homo sapiens ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1, mRNA
NCBI Official Synonym Full Names
ATPase H+ transporting V0 subunit d1
NCBI Official Synonym Symbols
P39; VATX; VMA6; ATP6D; ATP6DV; VPATPD [Similar Products]
NCBI Protein Information
V-type proton ATPase subunit d 1
UniProt Protein Name
V-type proton ATPase subunit d 1
UniProt Synonym Protein Names
32 kDa accessory protein; V-ATPase 40 kDa accessory protein; V-ATPase AC39 subunit; p39; Vacuolar proton pump subunit d 1
UniProt Synonym Gene Names
UniProt Entry Name
VA0D1_HUMAN
NCBI Summary for ATP6V0D1
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP6V0D1
ATP6V0D1: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. Belongs to the V-ATPase V0D/AC39 subunit family.
Protein type: Energy Metabolism - oxidative phosphorylation; Hydrolase; Vesicle; EC 3.6.3.14
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: centrosome; endosome membrane; lysosomal membrane; membrane; phagocytic vesicle membrane; vacuolar proton-transporting V-type ATPase complex
Molecular Function: protein binding
Biological Process: cilium biogenesis; insulin receptor signaling pathway; transferrin transport
Research Articles on ATP6V0D1
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Pathways associated with ATP6V0D1 cdna clone
Diseases associated with ATP6V0D1 cdna clone
Organs/Tissues associated with ATP6V0D1 cdna clone
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