BC015899
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,348 Da
NCBI Official Full Name
Homo sapiens ATPase, H+ transporting V0 subunit e2, mRNA
NCBI Official Synonym Full Names
ATPase H+ transporting V0 subunit e2
NCBI Protein Information
V-type proton ATPase subunit e 2
UniProt Protein Name
V-type proton ATPase subunit e 2
UniProt Synonym Protein Names
Lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2; Vacuolar proton pump subunit e 2
UniProt Synonym Gene Names
UniProt Entry Name
VA0E2_HUMAN
NCBI Summary for ATP6V0E2
Multisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles, clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found in plasma membranes of specialized cells, where they play roles in urinary acidification, bone resorption, and sperm maturation. Multiple subunits form H(+)-ATPases, with proteins of the V1 class hydrolyzing ATP for energy to transport H+, and proteins of the V0 class forming an integral membrane domain through which H+ is transported. ATP6V0E2 encodes an isoform of the H(+)-ATPase V0 e subunit, an essential proton pump component (Blake-Palmer et al., 2007 [PubMed 17350184]).[supplied by OMIM, Mar 2008]
UniProt Comments for ATP6V0E2
ATP6V0E2: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase e1/e2 subunit family. Composed of at least 10 subunits. 4 isoforms of the human protein are produced by alternative splicing
Protein type: Transporter, iron; Membrane protein, multi-pass; Hydrolase; Transporter; Transporter, ion channel; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q36.1
Cellular Component: endosome membrane; membrane; phagocytic vesicle membrane
Molecular Function: ATPase activity, coupled to transmembrane movement of ions; hydrogen ion transporting ATPase activity, rotational mechanism
Biological Process: cell growth; insulin receptor signaling pathway; transferrin transport; vacuolar acidification
Research Articles on ATP6V0E2
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Pathways associated with ATP6V0E2 cdna clone
Diseases associated with ATP6V0E2 cdna clone
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