BC012142
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,865 Da
NCBI Official Full Name
Homo sapiens ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2, mRNA
NCBI Official Synonym Full Names
ATPase H+ transporting V1 subunit C2
NCBI Official Synonym Symbols
NCBI Protein Information
V-type proton ATPase subunit C 2
UniProt Protein Name
V-type proton ATPase subunit C 2
UniProt Synonym Protein Names
Vacuolar proton pump subunit C 2
UniProt Synonym Gene Names
UniProt Entry Name
VATC2_HUMAN
NCBI Summary for ATP6V1C2
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP6V1C2
ATP6V1C2: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase C subunit family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.3.14; Hydrolase; Energy Metabolism - oxidative phosphorylation
Chromosomal Location of Human Ortholog: -
Cellular Component: cytosol; lysosomal membrane
Molecular Function: protein dimerization activity
Biological Process: insulin receptor signaling pathway; positive regulation of Wnt receptor signaling pathway; transferrin transport
Research Articles on ATP6V1C2
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Pathways associated with ATP6V1C2 cdna clone
Diseases associated with ATP6V1C2 cdna clone
Organs/Tissues associated with ATP6V1C2 cdna clone
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