BC111730
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
91,163 Da
NCBI Official Full Name
Homo sapiens advillin, mRNA
NCBI Official Synonym Full Names
advillin
NCBI Protein Information
advillin
UniProt Protein Name
Advillin
UniProt Synonym Protein Names
p92
UniProt Entry Name
AVIL_HUMAN
NCBI Summary for AVIL
The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia. [provided by RefSeq, Jul 2008]
UniProt Comments for AVIL
AVIL: Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. Belongs to the villin/gelsolin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q14.1
Cellular Component: actin cytoskeleton; cell projection; neuron projection
Molecular Function: actin binding
Biological Process: nervous system development
Research Articles on AVIL
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Diseases associated with AVIL cdna clone
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