BC002431
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,764 Da
NCBI Official Full Name
Homo sapiens cDNA clone IMAGE:3347310, containing frame-shift errors
NCBI Official Synonym Full Names
beta-1,4-galactosyltransferase 2
NCBI Official Synonym Symbols
B4Gal-T2; B4Gal-T3; beta4Gal-T2 [Similar Products]
NCBI Protein Information
beta-1,4-galactosyltransferase 2
UniProt Protein Name
Beta-1,4-galactosyltransferase 2
UniProt Synonym Protein Names
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2Including the following 4 domains:Lactose synthase A protein (EC:2.4.1.22)N-acetyllactosamine synthase (EC:2.4.1.90)Alternative name(s):Nal synthase
UniProt Synonym Gene Names
UniProt Entry Name
B4GT2_HUMAN
NCBI Summary for B4GALT2
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
UniProt Comments for B4GALT2
B4GALT2: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose. Belongs to the glycosyltransferase 7 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Glycan Metabolism - N-glycan biosynthesis; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.90; Carbohydrate Metabolism - galactose; EC 2.4.1.38; Membrane protein, integral; Glycan Metabolism - keratan sulfate biosynthesis; EC 2.4.1.22; Transferase
Chromosomal Location of Human Ortholog: 1p34-p33
Cellular Component: Golgi membrane
Molecular Function: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; galactosyltransferase activity
Biological Process: keratan sulfate biosynthetic process
Research Articles on B4GALT2
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Pathways associated with B4GALT2 cdna clone
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