BC014020
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,430 Da
NCBI Official Full Name
Homo sapiens BAI1-associated protein 2, mRNA
NCBI Official Synonym Full Names
BAI1 associated protein 2
NCBI Protein Information
brain-specific angiogenesis inhibitor 1-associated protein 2
UniProt Protein Name
Brain-specific angiogenesis inhibitor 1-associated protein 2
UniProt Synonym Protein Names
Fas ligand-associated factor 3; FLAF3; Insulin receptor substrate p53/p58; IRS-58; IRSp53/58; Insulin receptor substrate protein of 53 kDa; IRSp53; Insulin receptor substrate p53
UniProt Synonym Gene Names
BAI-associated protein 2; BAI1-associated protein 2; Protein BAP2; FLAF3; IRS-58; IRSp53/58; IRSp53; Insulin receptor substrate p53 [Similar Products]
UniProt Entry Name
BAIP2_HUMAN
NCBI Summary for BAIAP2
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
UniProt Comments for BAIAP2
IRSp53: Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1. Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP motifs). Interacts with E.coli intimin receptor Tir. Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: actin cytoskeleton; cell-cell adherens junction; cytoplasm; cytosol; plasma membrane
Molecular Function: identical protein binding; protein binding; protein C-terminus binding
Biological Process: actin crosslink formation; actin filament bundle formation; axonogenesis; insulin receptor signaling pathway; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; response to bacterium; vascular endothelial growth factor receptor signaling pathway
Research Articles on BAIAP2
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Pathways associated with BAIAP2 cdna clone
Diseases associated with BAIAP2 cdna clone
Organs/Tissues associated with BAIAP2 cdna clone
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