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C1QC cdna clone

Scan QR to view Datasheet Catalog #    MBS1267971 C1QC cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C1QC, cDNA Clone

★Popular Item★
 Also Known As   

C1QC cDNA Clone

 Product Gene Name   

C1QC cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggacgtgg ggcccagctc cctgccccac cttgggctga agctgctgct gctcctgctg ctgctgcccc tcaggggcca agccaacaca ggctgctacg ggatcccagg gatgcccggc ctgcctgggg caccagggaa ggatgggtac gacggactgc cggggcccaa gggggagcca ggaatcccag ccattcccgg gatccgagga cccaaagggc agaagggaga acccggctta cccggccatc ctgggaaaaa tggccccatg ggaccccctg ggatgccagg ggtgcccggc cccatgggca tccctggaga gccaggtgag gagggcagat acaagcagaa attccagtca gtgttcacgg tcactcggca gacccaccag ccccctgcac ccaacagcct gatcagattc aacgcggtcc tcaccaaccc gcagggagat tatgacacga gcactggcaa gttcacctgc aaagtccccg gcctctacta ctttgtctac cacgcgtcgc atacagccaa cctgtgcgtg ctgctgtacc gcagcggcgt caaagtggtc accttctgtg gccacacgtc caaaaccaat caggtcaact cgggcggtgt gctgctgagg ttgcaggtgg gcgaggaggt gtggctggct gtcaatgact actacgacat ggtgggcatc cagggctctg acagcgtctt ctccggcttc ctgctcttcc ccgactag
 OMIM    120575
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of C1QC cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for C1QC. It may not necessarily be applicable to this product.
 NCBI GI #    14290495
 NCBI GeneID    714
 NCBI Accession #    BC009016 [Other Products]
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 UniProt Secondary Accession #    Q7Z502; Q96DL2; Q96H05 [Other Products]
 UniProt Related Accession #    P02747 [Other Products]
 Molecular Weight    25,774 Da
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 NCBI Official Full Name    Homo sapiens complement component 1, q subcomponent, C chain, mRNA
 NCBI Official Synonym Full Names    complement C1q C chain
 NCBI Official Symbol    C1QC [Similar Products]
 NCBI Official Synonym Symbols   
C1QG; C1Q-C
[Similar Products]
 NCBI Protein Information    complement C1q subcomponent subunit C
 UniProt Protein Name    Complement C1q subcomponent subunit C
 Protein Family    Complement C1q subcomponent
 UniProt Gene Name    C1QC [Similar Products]
 UniProt Synonym Gene Names    C1QG [Similar Products]
 UniProt Entry Name    C1QC_HUMAN
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 NCBI Summary for C1QC    This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C1QC    C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: extracellular region; extracellular space

Molecular Function: serine-type endopeptidase activity

Biological Process: complement activation; complement activation, classical pathway; negative regulation of granulocyte differentiation; negative regulation of macrophage differentiation

Disease: C1q Deficiency
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 Research Articles on C1QC    1. Neuromyelitis optica patients had higher levels of C3a and anti-C1q antibodies than healthy controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with C1QC cdna cloneDiseases associated with C1QC cdna clone
 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with C1QC and Nervous System Diseases
 Kidney Diseases Antibodies  >2 publications with C1QC and Kidney Diseases
 Skin Neoplasms Antibodies  >1 publications with C1QC and Skin Neoplasms
 Carcinoma Antibodies  >1 publications with C1QC and Carcinoma
 Adenocarcinoma Antibodies  >1 publications with C1QC and Adenocarcinoma
 Liver Neoplasms Antibodies  >1 publications with C1QC and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with C1QC and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with C1QC and Carcinoma, Hepatocellular
 Neoplasms Antibodies  >1 publications with C1QC and Neoplasms
Organs/Tissues associated with C1QC cdna clone
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >2 publications with C1QC and Embryonic Tissue
 Vascular Antibodies  >2 publications with C1QC and Vascular
 Bone Marrow Antibodies  >1 publications with C1QC and Bone Marrow
 Liver Antibodies  >1 publications with C1QC and Liver
 Spleen Antibodies  >1 publications with C1QC and Spleen
 Kidney Antibodies  >1 publications with C1QC and Kidney
 Brain Antibodies  >1 publications with C1QC and Brain
 Placenta Antibodies  >1 publications with C1QC and Placenta
 Lung Antibodies  >1 publications with C1QC and Lung
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