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C5 cdna clone

Scan QR to view Datasheet Catalog #    MBS1269057 C5 cdna clone
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C5, cDNA Clone

 Also Known As   

C5 cDNA Clone

 Product Gene Name   

C5 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Application Notes    The full plasmid sequence is not standardly provided for this product. Sequencing report may be available for an additional fee with cDNA product purchase, please inquire.
 Sequence    atgggccttt tgggaatact ttgtttttta atcttcctgg ggaaaacctg gggacaggag caaacatatg tcatttcagc accaaaaata ttccgtgttg gagcatctga aaatattgtg attcaagttt atggatacac tgaagcattt gatgcaacaa tctctattaa aagttatcct gataaaaaat ttagttactc ctcaggccat gttcatttat cctcagagaa taaattccaa aactctgcaa tcttaacaat acaaccaaaa caattgcctg gaggacaaaa cccagtttct tatgtgtatt tggaagttgt atcaaagcat ttttcaaaat caaaaagaat gccaataacc tatgacaatg gatttctctt cattcataca gacaaacctg tttatactcc agaccagtca gtaaaagtta gagtttattc gttgaatgac gacttgaagc cagccaaaag agaaactgtc ttaactttca tagatcctga aggatcagaa gttgacatgg tagaagaaat tgatcatatt ggaattatct cttttcctga cttcaagatt ccgtctaatc ctagatatgg tatgtggacg atcaaggcta aatataaaga ggacttttca acaactggaa ccgcatattt tgaagttaaa gaatatgtct tgccacattt ttctgtctca atcgagccag aatataattt cattggttac aagaacttta agaattttga aattactata aaagcaagat atttttataa taaagtagtc actgaggctg acgtttatat cacatttgga ataagagaag acttaaaaga tgatcaaaaa gaaatgatgc aaacagcaat gcaaaacaca atgttgataa atggaattgc tcaagtcaca tttgattctg aaacagcagt caaagaactg tcatactaca gtttagaaga tttaaacaac aagtaccttt atattgctgt aacagtcata gagtctacag gtggattttc tgaagaggca gaaatacctg gcatcaaata tgtcctctct ccctacaaac tgaatttggt tgctactcct cttttcctga agcctgggat tccatatccc atcaaggtgc aggttaaaga ttcgcttgac cagttggtag gaggagtccc agtaacactg aatgcacaaa caattgatgt aaaccaagag acatctgact tggatccaag caaaagtgta acacgtgttg atgatggagt agcttccttt gtgcttaatc tcccatctgg agtgacggtg ctggagttta atgtcaaaac tgatgctcca gatcttccag aagaaaatca ggccagggaa ggttaccgag caatagcata ctcatctctc agccaaagtt acctttatat tgattggact gataaccata aggctttgct agtgggagaa catctgaata ttattgttac ccccaaaagc ccatatattg acaaaataac tcactataat tacttgattt tatccaaggg caaaattatc cactttggca cgagggagaa attttcagat gcatcttatc aaagtataaa cattccagta acacagaaca tggttccttc atcccgactt ctggtctatt acatcgtcac aggagaacag acagcagaat tagtgtctga ttcagtctgg ttaaatattg aagaaaaatg tggcaaccag ctccaggttc atctgtctcc tgatgcagat gcatattctc caggccaaac tgtgtctctt aatatggcaa ctggaatgga ttcctgggtg gcattagcag cagtggacag tgctgtgtat ggagtccaaa gaggagccaa aaagcccttg gaaagagtat ttcaattctt agagaagagt gatctgggct gtggggcagg tggtggcctc aacaatgcca atgtgttcca cctagctgga cttaccttcc tcactaatgc aaatgcagat gactcccaag aaaatgatga accttgtaaa gaaattctca ggccaagaag aacgctgcaa aagaagatag aagaaatagc tgctaaatat aaacattcag tagtgaagaa atgttgttac gatggagcct gcgttaataa tgatgaaacc tgtgagcagc gagctgcacg gattagttta gggccaagat gcatcaaagc tttcactgaa tgttgtgtcg tcgcaagcca gctccgtgct aatatctctc ataaagacat gcaattggga aggctacaca tgaagaccct gttaccagta agcaagccag aaattcggag ttattttcca gaaagctggt tgtgggaagt tcatcttgtt cccagaagaa aacagttgca gtttgcccta cctgattctc taaccacctg ggaaattcaa ggcgttggca tttcaaacac tggtatatgt gttgctgata ctgtcaaggc aaaggtgttc aaagatgtct tcctggaaat gaatatacca tattctgttg tacgaggaga acagatccaa ttgaaaggaa ctgtttacaa ctataggact tctgggatgc agttctgtgt taaaatgtct gctgtggagg gaatctgcac ttcggaaagc ccagtcattg atcatcaggg cacaaagtcc tccaaatgtg tgcgccagaa agtagagggc tcctccagtc acttggtgac attcactgtg cttcctctgg aaattggcct tcacaacatc aatttttcac tggagacttg gtttggaaaa gaaatcttag taaaaacatt acgagtggtg ccagaaggtg tcaaaaggga aagctattct ggtgttactt tggatcctag gggtatttat ggtaccatta gcagacgaaa ggagttccca tacaggatac ccttagattt ggtccccaaa acagaaatca aaaggatttt gagtgtaaaa ggactgcttg taggtgagat cttgtctgca gttctaagtc aggaaggcat caatatccta acccacctcc ccaaagggag tgcagaggcg gagctgatga gcgttgtccc agtattctat gtttttcact acctggaaac aggaaatcat tggaacattt ttcattctga cccattaatt gaaaagcaga aactgaagaa aaaattaaaa gaagggatgt tgagcattat gtcctacaga aatgctgact actcttacag tgtgtggaag ggtggaagtg ctagcacttg gttaacagct tttgctttaa gagtacttgg acaagtaaat aaatacgtag agcagaacca aaattcaatt tgtaattctt tattgtggct agttgagaat tatcaattag ataatggatc tttcaaggaa aattcacagt atcaaccaat aaaattacag ggtaccttgc ctgttgaagc ccgagagaac agcttatatc ttacagcctt tactgtgatt ggaattagaa aggctttcga tatatgcccc ctggtgaaaa tcgacacagc tctaattaaa gctgacaact ttctgcttga aaatacactg ccagcccaga gcacctttac attggccatt tctgcgtatg ctctttccct gggagataaa actcacccac agtttcgttc aattgtttca gctttgaaga gagaagcttt ggttaaaggt aatccaccca tttatcgttt ttggaaagac aatcttcagc ataaagacag ctctgtacct aacactggta cggcacgtat ggtagaaaca actgcctatg ctttactcac cagtctgaac ttgaaagata taaattatgt taacccagtc atcaaatggc tatcagaaga gcagaggtat ggaggtggct tttattcaac ccaggacaca atcaatgcca ttgagggcct gacggaatat tcactcctgg ttaaacaact ccgcttgagt atggacatcg atgtttctta caagcataaa ggtgccttac ataattataa aatgacagac aagaatttcc ttgggaggcc agtagaggtg cttctcaatg atgacctcat tgtcagtaca ggatttggca gtggcttggc tacagtacat gtaacaactg tagttcacaa aaccagtacc tctgaggaag tttgcagctt ttatttgaaa atcgatactc aggatattga agcatcccac tacagaggct acggaaactc tgattacaaa cgcatagtag catgtgccag ctacaagccc agcagggaag aatcatcatc tggatcctct catgcggtga tggacatctc cttgcctact ggaatcagtg caaatgaaga agacttaaaa gcccttgtgg aaggggtgga tcaactattc actgattacc aaatcaaaga tggacatgtt attctgcaac tgaattcgat tccctccagt gatttccttt gtgtacgatt ccggatattt gaactctttg aagttgggtt tctcagtcct gccactttca cagtgtacga ataccacaga ccagataaac agtgtaccat gttttatagc acttccaata tcaaaattca gaaagtctgt gaaggagccg cgtgcaagtg tgtagaagct gattgtgggc aaatgcagga agaattggat ctgacaatct ctgcagagac aagaaaacaa acagcatgta aaccagagat tgcatatgct tataaagtta gcatcacatc catcactgta gaaaatgttt ttgtcaagta caaggcaacc cttctggata tctacaaaac tggggaagct gttgctgaga aagactctga gattaccttc attaaaaagg taacctgtac taacgctgag ctggtaaaag gaagacagta cttaattatg ggtaaagaag ccctccagat aaaatacaat ttcagtttca ggtacatcta ccctttagat tccttgacct ggattgaata ctggcctaga gacacaacat gttcatcgtg tcaagcattt ttagctaatt tagatgaatt tgccgaagat atctttttaa atggatgcta a
 OMIM    120900
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of C5 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for C5. It may not necessarily be applicable to this product.
 NCBI GI #    109731392
 NCBI GeneID    727
 NCBI Accession #    BC113740 [Other Products]
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 UniProt Secondary Accession #    Q14CJ0; Q27I61 [Other Products]
 UniProt Related Accession #    P01031 [Other Products]
 Molecular Weight    188,305 Da
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 NCBI Official Full Name    Homo sapiens complement component 5, mRNA
 NCBI Official Synonym Full Names    complement C5
 NCBI Official Symbol    C5 [Similar Products]
 NCBI Official Synonym Symbols   
C5D; C5a; C5b; ECLZB; CPAMD4
[Similar Products]
 NCBI Protein Information    complement C5
 UniProt Protein Name    Complement C5
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
 Protein Family    C5a peptidase
 UniProt Gene Name    C5 [Similar Products]
 UniProt Synonym Gene Names    CPAMD4 [Similar Products]
 UniProt Entry Name    CO5_HUMAN
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 NCBI Summary for C5    This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
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 UniProt Comments for C5    C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q33-q34

Cellular Component: extracellular region

Molecular Function: chemokine activity; protein binding; receptor binding

Biological Process: activation of MAPK activity; cell surface receptor linked signal transduction; chemotaxis; complement activation; G-protein coupled receptor protein signaling pathway; regulation of complement activation; response to stress

Disease: Complement Component 5 Deficiency; Eculizumab, Poor Response To
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 Research Articles on C5    1. C5 rs2269067 GG genotype confers risk for proliferative diabetic retinopathy of type 2 diabetes in Chinese Han population (associated with an elevated C5 mRNA expression and an increased IL-6 production)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with C5 cdna cloneDiseases associated with C5 cdna clone
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2007 publications with C5 and Nervous System Diseases
 Neurologic Manifestations Antibodies  >844 publications with C5 and Neurologic Manifestations
 Inflammation Antibodies  >650 publications with C5 and Inflammation
 Cardiovascular Diseases Antibodies  >590 publications with C5 and Cardiovascular Diseases
 Complement component 5 deficiency Antibodies  >577 publications with C5 and Complement component 5 deficiency
 Autoimmune Diseases Antibodies  >433 publications with C5 and Autoimmune Diseases
 Hemolysis Antibodies  >428 publications with C5 and Hemolysis
 Kidney Diseases Antibodies  >371 publications with C5 and Kidney Diseases
 Necrosis Antibodies  >208 publications with C5 and Necrosis
 Anemia Antibodies  >174 publications with C5 and Anemia
Organs/Tissues associated with C5 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1898 publications with C5 and Bone
 Muscle Antibodies  >1145 publications with C5 and Muscle
 Brain Antibodies  >681 publications with C5 and Brain
 Lung Antibodies  >440 publications with C5 and Lung
 Kidney Antibodies  >419 publications with C5 and Kidney
 Liver Antibodies  >403 publications with C5 and Liver
 Spleen Antibodies  >164 publications with C5 and Spleen
 Bone Marrow Antibodies  >112 publications with C5 and Bone Marrow
 Intestine Antibodies  >109 publications with C5 and Intestine
 Eye Antibodies  >89 publications with C5 and Eye
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