BC069612
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,966 Da
NCBI Official Full Name
Homo sapiens calcium channel, voltage-dependent, gamma subunit 2, mRNA
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit gamma 2
NCBI Official Synonym Symbols
NCBI Protein Information
voltage-dependent calcium channel gamma-2 subunit
UniProt Protein Name
Voltage-dependent calcium channel gamma-2 subunit
UniProt Synonym Protein Names
Neuronal voltage-gated calcium channel gamma-2 subunit; Transmembrane AMPAR regulatory protein gamma-2; TARP gamma-2
UniProt Synonym Gene Names
UniProt Entry Name
CCG2_HUMAN
NCBI Summary for CACNG2
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
UniProt Comments for CACNG2
Stargazin: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1. Brain. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: plasma membrane
Molecular Function: calcium channel activity; channel regulator activity; protein binding
Biological Process: membrane depolarization; transmission of nerve impulse; transport
Disease: Mental Retardation, Autosomal Dominant 10
Research Articles on CACNG2
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Pathways associated with CACNG2 cdna clone
Diseases associated with CACNG2 cdna clone
Organs/Tissues associated with CACNG2 cdna clone
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