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CAPN3 cdna clone

Scan QR to view Datasheet Catalog #    MBS1266191 CAPN3 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CAPN3, cDNA Clone

★Popular Item★
 Also Known As   

CAPN3 cDNA Clone

 Product Gene Name   

CAPN3 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgcacggga acaagcagca cctgcagaag gacttcttcc tgtacaacgc ctccaaggcc aggagcaaaa cctacatcaa catgcgggag gtgtcccagc gcttccgcct gcctcccagc gagtacgtca tcgtgccctc cacctacgag ccccaccagg agggggaatt catcctccgg gtcttctctg aaaagaggaa cctctctgag gaagttgaaa ataccatctc cgtggatcgg ccagtgaaaa agaaaaaaac caagcccatc atcttcgttt cggacagagc aaacagcaac aaggagctgg gtgtggacca ggagtcagag gagggcaaag gcaaaacaag ccctgataag caaaagcagt ccccacagcc acagcctggc agctctgatc aggaaagtga ggaacagcaa caattccgga acattttcaa gcagatagca ggagatgaca tggagatctg tgcagatgag ctcaagaagg tccttaacac agtcgtgaac aaacacaagg acctgaagac acacgggttc acactggagt cctgccgtag catgattgcg ctcatggata cagatggctc tggaaagctc aacctgcagg agttccacca cctctggaac aagattaagg cctggcagaa aattttcaaa cactatgaca cagaccagtc cggcaccatc aacagctacg agatgcgaaa tgcagtcaac gacgcaggat tccacctcaa caaccagctc tatgacatca ttaccatgcg gtacgcagac aaacacatga acatcgactt tgacagtttc atctgctgct tcgttaggct ggagggcatg ttcagagctt ttcatgcatt tgacaaggat ggagatggta tcatcaagct caacgttctg gagtggctgc agctcaccat gtatgcctga
 OMIM    114240
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CAPN3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for CAPN3. It may not necessarily be applicable to this product.
 NCBI GI #    13111992
 NCBI GeneID    825
 NCBI Accession #    BC003169 [Other Products]
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 UniProt Secondary Accession #    Q7L4R0; Q9BQC8; Q9BTU4; Q9Y5S6; Q9Y5S7; A6H8K6 [Other Products]
 UniProt Related Accession #    P20807 [Other Products]
 Molecular Weight    18,246 Da
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 NCBI Official Full Name    Homo sapiens calpain 3, (p94), mRNA
 NCBI Official Synonym Full Names    calpain 3
 NCBI Official Symbol    CAPN3 [Similar Products]
 NCBI Official Synonym Symbols   
p94; CANP3; LGMD2; nCL-1; CANPL3; LGMD2A
[Similar Products]
 NCBI Protein Information    calpain-3
 UniProt Protein Name    Calpain-3
 UniProt Synonym Protein Names   
Calcium-activated neutral proteinase 3; CANP 3; Calpain L3; Calpain p94; Muscle-specific calcium-activated neutral protease 3; New calpain 1; nCL-1
 Protein Family    Calpain
 UniProt Gene Name    CAPN3 [Similar Products]
 UniProt Synonym Gene Names    CANP3; CANPL3; NCL1; CANP 3; nCL-1 [Similar Products]
 UniProt Entry Name    CAN3_HUMAN
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 NCBI Summary for CAPN3    Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CAPN3    CAPN3: Calcium-regulated non-lysosomal thiol-protease. Defects in CAPN3 are the cause of limb-girdle muscular dystrophy type 2A (LGMD2A). LGMD2A is an autosomal recessive degenerative myopathy characterized by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase. The symptoms usually begin during the first two decades of life, and the disease gradually worsens, often resulting in loss of walking ability 10 or 20 years after onset. Belongs to the peptidase C2 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Motility/polarity/chemotaxis; Cell development/differentiation; EC 3.4.22.54; Calcium-binding

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: cytoplasm; cytosol; intracellular; myofibril; nucleus; plasma membrane; protein complex; T-tubule; Z disc

Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; catalytic activity; cysteine-type peptidase activity; ligase regulator activity; peptidase activity; protein binding; protein complex scaffold; signal transducer activity; sodium ion binding; structural constituent of muscle; titin binding

Biological Process: activation of NF-kappaB transcription factor; apoptosis; muscle development; muscle maintenance; myofibril assembly; negative regulation of apoptosis; negative regulation of protein sumoylation; negative regulation of transcription, DNA-dependent; positive regulation of proteolysis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of satellite cell activation involved in skeletal muscle regeneration; positive regulation of transcription, DNA-dependent; protein complex assembly; proteolysis; regulation of catalytic activity; regulation of I-kappaB kinase/NF-kappaB cascade; response to calcium ion; response to muscle activity; sarcomere organization

Disease: Muscular Dystrophy, Limb-girdle, Type 2a
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 Research Articles on CAPN3    1. We identified four novel CAPN3 mutations and demonstrated clinical and pathological heterogeneity in Korean patients with calpainopathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CAPN3 cdna cloneDiseases associated with CAPN3 cdna clone
 Products by Pathway  Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >147 publications with CAPN3 and Nervous System Diseases
 Muscular Diseases Antibodies  >146 publications with CAPN3 and Muscular Diseases
 Limb-girdle muscular dystrophy type 2A Antibodies  >81 publications with CAPN3 and Limb-girdle muscular dystrophy type 2A
 Necrosis Antibodies  >10 publications with CAPN3 and Necrosis
 Neoplasms Antibodies  >7 publications with CAPN3 and Neoplasms
 Mental Disorders Antibodies  >3 publications with CAPN3 and Mental Disorders
 Cardiovascular Diseases Antibodies  >3 publications with CAPN3 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >2 publications with CAPN3 and Neoplasms, Experimental
 Weight Loss Antibodies  >2 publications with CAPN3 and Weight Loss
 Liver Diseases Antibodies  >1 publications with CAPN3 and Liver Diseases
Organs/Tissues associated with CAPN3 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >210 publications with CAPN3 and Muscle
 Blood Antibodies  >16 publications with CAPN3 and Blood
 Brain Antibodies  >15 publications with CAPN3 and Brain
 Nerve Antibodies  >14 publications with CAPN3 and Nerve
 Heart Antibodies  >7 publications with CAPN3 and Heart
 Embryonic Tissue Antibodies  >4 publications with CAPN3 and Embryonic Tissue
 Eye Antibodies  >3 publications with CAPN3 and Eye
 Testis Antibodies  >2 publications with CAPN3 and Testis
 Connective Tissue Antibodies  >2 publications with CAPN3 and Connective Tissue
 Kidney Antibodies  >1 publications with CAPN3 and Kidney
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