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CD74 cdna clone

Scan QR to view Datasheet Catalog #    MBS1268628 CD74 cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD74, cDNA Clone

★Popular Item★
 Also Known As   

CD74 cDNA Clone

 Product Gene Name   

CD74 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 Chromosome Location    Chromosome: 5; NC_000005.9 (149781200..149792499, complement). Location: 5q32
 OMIM    142790
 3D Structure    ModBase 3D Structure for P04233
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 Vector    Please Inquire
 Accession Number    BC018726
 Insert site    rrnB_T1, rrnB_T2
 Gene ID    972
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CD74 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CD74 cdna clone

   Homo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain, mRNA (cDNA clone MGC:31825 IMAGE:4853578), complete cds.
NCBI/Uniprot data below describe general gene information for CD74. It may not necessarily be applicable to this product.
 NCBI GI #    17511739
 NCBI GeneID    972
 NCBI Accession #    BC018726 [Other Products]
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 UniProt Primary Accession #    P04233 [Other Products]
 UniProt Secondary Accession #    Q14597; Q29832; Q5U0J8; Q8SNA0; Q8WLP6; A8K7R1; B4DNE8; D3DQG3; D3DQG4 [Other Products]
 UniProt Related Accession #    P04233 [Other Products]
 Molecular Weight    33,516 Da
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 NCBI Official Full Name    Homo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain, mRNA
 NCBI Official Synonym Full Names    CD74 molecule, major histocompatibility complex, class II invariant chain
 NCBI Official Symbol    CD74 [Similar Products]
 NCBI Official Synonym Symbols   
II; DHLAG; HLADG; Ia-GAMMA
[Similar Products]
 NCBI Protein Information    HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
 UniProt Protein Name    HLA class II histocompatibility antigen gamma chain
 UniProt Synonym Protein Names   
HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; p33
 Protein Family    H-2 class II histocompatibility antigen
 UniProt Gene Name    CD74 [Similar Products]
 UniProt Synonym Gene Names    DHLAG; Ii [Similar Products]
 UniProt Entry Name    HG2A_HUMAN
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 NCBI Summary for CD74    The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
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 UniProt Comments for CD74    CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: Golgi membrane; multivesicular body; lysosomal lumen; cell surface; membrane; lysosomal membrane; plasma membrane; integral to membrane; trans-Golgi network membrane; vacuole; intracellular; MHC class II protein complex; external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; identical protein binding; protein binding; beta-amyloid binding; cytokine binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase binding; MHC class II protein binding

Biological Process: activation of MAPK activity; positive regulation of dendritic cell antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; defense response; prostaglandin biosynthetic process; signal transduction; negative regulation of T cell differentiation; intracellular protein transport; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of fibroblast proliferation; negative regulation of mature B cell apoptosis; positive regulation of B cell proliferation; protein complex assembly; positive thymic T cell selection; negative regulation of peptide secretion; positive regulation of T-helper 2 type immune response; chaperone cofactor-dependent protein folding; regulation of macrophage activation; T cell selection; negative thymic T cell selection; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; immunoglobulin mediated immune response; positive regulation of cytokine and chemokine mediated signaling pathway; antigen processing and presentation of endogenous antigen; negative regulation of apoptosis
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 Research Articles on CD74    1. Ii regulates the repertoire of tumor peptides presented by major histocompatibility complex class II+ breast cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CD74 cdna cloneDiseases associated with CD74 cdna clone
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >146 publications with CD74 and Neoplasms
 Inflammation Antibodies  >57 publications with CD74 and Inflammation
 Carcinoma Antibodies  >42 publications with CD74 and Carcinoma
 Adenocarcinoma Antibodies  >20 publications with CD74 and Adenocarcinoma
 Disease Models, Animal Antibodies  >17 publications with CD74 and Disease Models, Animal
 Brain Diseases Antibodies  >13 publications with CD74 and Brain Diseases
 Kidney Diseases Antibodies  >12 publications with CD74 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >11 publications with CD74 and Neoplasms, Experimental
 Necrosis Antibodies  >11 publications with CD74 and Necrosis
 Lung Neoplasms Antibodies  >10 publications with CD74 and Lung Neoplasms
Organs/Tissues associated with CD74 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >117 publications with CD74 and Blood
 Bone Antibodies  >34 publications with CD74 and Bone
 Brain Antibodies  >29 publications with CD74 and Brain
 Bone Marrow Antibodies  >28 publications with CD74 and Bone Marrow
 Lung Antibodies  >24 publications with CD74 and Lung
 Lymph Antibodies  >23 publications with CD74 and Lymph
 Lymph Node Antibodies  >21 publications with CD74 and Lymph Node
 Vascular Antibodies  >19 publications with CD74 and Vascular
 Kidney Antibodies  >18 publications with CD74 and Kidney
 Stomach Antibodies  >17 publications with CD74 and Stomach
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