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DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

CD82 cdna clone

Scan QR to view Datasheet Catalog #    MBS1276943 CD82 cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD82, cDNA Clone

 Also Known As   

CD82 cDNA Clone

 Product Gene Name   

CD82 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    600623
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CD82 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for CD82. It may not necessarily be applicable to this product.
 NCBI GI #    33875790
 NCBI GeneID    3732
 NCBI Accession #    BC000726 [Other Products]
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 UniProt Secondary Accession #    Q7Z2D4; Q7Z5N2; D3DQN6; E9PC70 [Other Products]
 UniProt Related Accession #    P27701 [Other Products]
 Molecular Weight    26,818 Da
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 NCBI Official Full Name    Homo sapiens CD82 molecule, mRNA
 NCBI Official Synonym Full Names    CD82 molecule
 NCBI Official Symbol    CD82 [Similar Products]
 NCBI Official Synonym Symbols   
R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27
[Similar Products]
 NCBI Protein Information    CD82 antigen
 UniProt Protein Name    CD82 antigen
 UniProt Synonym Protein Names   
C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27; CD_antigen: CD82
 Protein Family    CD82 antigen
 UniProt Gene Name    CD82 [Similar Products]
 UniProt Synonym Gene Names    KAI1; SAR2; ST6; TSPAN27; Tspan-27 [Similar Products]
 UniProt Entry Name    CD82_HUMAN
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 NCBI Summary for CD82    This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD82    CD82: a widespread transmembrane protein of the tetraspanin family. A metastasis-suppressor whose decreased expression may be involved in malignant progression. Suppresses tumor metastasis of many cancers including cancers of the prostate, bladder, colon, cervix, liver, and lung (NSCLC). It is a target of estrogen receptor-mediated gene repression and is downregulated in primary human breast cancer. May be a prognostic marker for lung cancer and tumor metastatic potential. Interacts with cell surface proteins including integrins, cadherins, CD4, CD8, IGSF8. Modulates EGFR signaling. May suppress invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Its regulation of c-Met signaling apparently affects cancer cell migration.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: cell surface receptor linked signal transduction

Disease: Prostate Cancer
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 Research Articles on CD82    1. KAI1 was able to suppress melanoma angiogenesis by downregulating IL-6 and VEGF expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CD82 cdna cloneDiseases associated with CD82 cdna clone
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >260 publications with CD82 and Neoplasms
 Neoplasm Metastasis Antibodies  >157 publications with CD82 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >52 publications with CD82 and Adenocarcinoma
 Prostatic Neoplasms Antibodies  >46 publications with CD82 and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >42 publications with CD82 and Prostatic Diseases
 Breast Neoplasms Antibodies  >27 publications with CD82 and Breast Neoplasms
 Liver Neoplasms Antibodies  >27 publications with CD82 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >16 publications with CD82 and Neoplasms, Experimental
 Hyperplasia Antibodies  >13 publications with CD82 and Hyperplasia
 Carcinoma, Hepatocellular Antibodies  >11 publications with CD82 and Carcinoma, Hepatocellular
Organs/Tissues associated with CD82 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >66 publications with CD82 and Blood
 Prostate Antibodies  >64 publications with CD82 and Prostate
 Lymph Node Antibodies  >56 publications with CD82 and Lymph Node
 Lymph Antibodies  >56 publications with CD82 and Lymph
 Lung Antibodies  >51 publications with CD82 and Lung
 Liver Antibodies  >30 publications with CD82 and Liver
 Stomach Antibodies  >17 publications with CD82 and Stomach
 Bone Marrow Antibodies  >11 publications with CD82 and Bone Marrow
 Uterus Antibodies  >11 publications with CD82 and Uterus
 Placenta Antibodies  >9 publications with CD82 and Placenta
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