Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow cDNA Clone rightarrow CDC73  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • ERCC8 Antibody
 • Glucose Regulated Protein 78 (GRP78) ELISA Kit
 • OCLN ELISA Kit
 • RELN ELISA Kit
 • Acti-vated protein C (APC) ELISA Kit
 • cross linked N-telopeptide of type I  collagen, NTX ELISA Kit
 • cAMP-dependent protein kinase type I-alpha regulatory subuni... Recombinant Protein
 • Vitellogenin (VTG) ELISA Kit
 • GSTtheta2-GSTt2 ELISA Kit
 • Activin A (ACTIVIN-A) ELISA Kit
 • Cytochrome c-type Heme Lyase (HCCS) Antibody
 • ANXA2 ELISA Kit
 • PDK1 Antibody
 • Mitochondrial brown fat uncoupling protein 1 (UCP1) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

CDC73 cdna clone

Scan QR to view Datasheet Catalog #    MBS1273132 CDC73 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDC73, cDNA Clone

★Popular Item★
 Also Known As   

CDC73 cDNA Clone

 Product Gene Name   

CDC73 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggcggacg tgcttagcgt cctgcgacag tacaacatcc agaagaagga gattgtggtg aagggagacg aagtgatctt cggggagttc tcctggccca agaatgtgaa gaccaactat gttgtttggg ggactggaaa ggaaggccaa cccagagagt actacacatt ggattccatt ttatttctac ttaataacgt gcacctttct catcctgttt atgtccgacg tgcagctact gaaaatattc ctgtggttag aagacctgat cgaaaagatc tacttggata tctcaatggt gaagcgtcaa catcggcaag tatagacaga agcgctccct tagaaatagg tcttcagcga tctactcaag tcaaacgagc tgcagatgaa gttttagcag aagcaaagaa accacgaatt gaggatgaag agtgtgtgcg ccttgataaa gagagattgg ctgcccgttt ggagggtcac aaagaaggga ttgtacagac tgaacagatt aggtctttgt ctgaagctat gtcagtggaa aaaattgctg caatcaaagc caaaattatg gctaagaaaa gatctactat caagactgat ctagatgatg acataactgc ccttaaacag aggagttttg tggatgctga ggtagatgtg acccgagata ttgtcagcag agagagagta tggaggacac gaacaactat cttacaaagc acaggaaaga atttttccaa gaacattttt gcaattcttc aatctgtaaa agccagagaa gaagggcgtg cacctgaaca gcgacctgcc ccaaatgcag cacctgtgga tcccactttg cgcaccaaac agcctatccc agctgcctat aacagatacg atcaggaaag attcaaagga aaagaagaaa cggaaggctt caaaattgac actatgggaa cctaccatgg tatgacactg aaatctgtaa cggagggtgc atctgcccgg aagactcaga ctcctgcagc ccagccagta ccaagaccag tttctcaagc aagacctccc ccaaatcaga agaaaggatc tcgaacaccc attatcataa ttcctgcagc taccacctct ttaataacca tgcttaatgc aaaagacctt ctacaggacc tgaaatttgt cccatcagat gaaaagaaga aacaaggttg tcaacgagaa aatgaaactc taatacaaag aagaaaagac cagatgcaac cagggggcac tgcaattagt gttacagtac cttatagagt agtagaccag ccccttaaac ttatgcctca agactgggac cgcgttgtag ccgtttttgt gcagggtcct gcatggcagt tcaaaggttg gccatggctt ttgcctgatg gatcaccagt tgatatattt gctaaaatta aagccttcca tctgaagtat gatgaagttc gtctggatcc aaatgttcag aaatgggatg taacagtatt agaactcagc tatcacaaac gtcatttgga tagaccagtg ttcttacggt tttgggaaac attggacagg tacatggtaa agcataaatc gcacttgaga ttctga
 OMIM    145000
Section Bar
Section Bar
Section Bar
 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
Section Bar
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CDC73 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CDC73. It may not necessarily be applicable to this product.
 NCBI GI #    40675603
 NCBI GeneID    79577
 NCBI Accession #    BC065037 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q6PK51; Q96A07; Q9H245; Q9H5L7; A6NLZ8; B2RBR2 [Other Products]
 UniProt Related Accession #    Q6P1J9 [Other Products]
 Molecular Weight    60,577 Da
Table BarTOPTable Bar
 NCBI Official Full Name    Homo sapiens cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae), mRNA
 NCBI Official Synonym Full Names    cell division cycle 73
 NCBI Official Symbol    CDC73 [Similar Products]
 NCBI Official Synonym Symbols   
HYX; FIHP; HPTJT; HRPT1; HRPT2; C1orf28
[Similar Products]
 NCBI Protein Information    parafibromin
 UniProt Protein Name    Parafibromin
 UniProt Synonym Protein Names   
Cell division cycle protein 73 homolog; Hyperparathyroidism 2 protein
 Protein Family    Cell division control protein
 UniProt Gene Name    CDC73 [Similar Products]
 UniProt Synonym Gene Names    C1orf28; HRPT2 [Similar Products]
 UniProt Entry Name    CDC73_HUMAN
Section Bar
 NCBI Summary for CDC73    This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]
Section Bar
 UniProt Comments for CDC73    CDC73: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of MLL1; it promotes leukemogenesis though association with MLL-rearranged oncoproteins, such as MLL-MLLT3/AF9 and MLL-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Interacts with POLR2A, CPSF1, CPSF4, CSTF2, MLL and CTNNB1. Interacts with a Set1-like complex that has histone methyltransferase activity and methylates histone H3. Found in a complex with BCL9L or BCL9, CDC73, CTNNB1 and PYGO1 indicative for the participation in a nuclear Wnt signaling complex. Found in adrenal and parathyroid glands, kidney and heart. Belongs to the CDC73 family.

Protein type: Cell cycle regulation; Tumor suppressor

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: endodermal cell fate commitment; histone H2B ubiquitination; histone monoubiquitination; mRNA polyadenylation; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mRNA 3'-end processing; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Wnt receptor signaling pathway; protein destabilization; stem cell maintenance

Disease: Parathyroid Carcinoma
Table BarTOPTable Bar
 Research Articles on CDC73    1. These findings suggest that downregulated expression of parafibromin protein plays an important role in the pathogenesis, differentiation, and metastasis of head and neck squamous cell carcinomas
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Diseases associated with CDC73 cdna cloneOrgans/Tissues associated with CDC73 cdna clone
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >127 publications with CDC73 and Neoplasms
 Hyperparathyroidism Antibodies  >121 publications with CDC73 and Hyperparathyroidism
 Parathyroid Neoplasms Antibodies  >113 publications with CDC73 and Parathyroid Neoplasms
 Carcinoma Antibodies  >78 publications with CDC73 and Carcinoma
 Kidney Diseases Antibodies  >17 publications with CDC73 and Kidney Diseases
 Adenocarcinoma Antibodies  >11 publications with CDC73 and Adenocarcinoma
 Lung Neoplasms Antibodies  >6 publications with CDC73 and Lung Neoplasms
 Breast Neoplasms Antibodies  >5 publications with CDC73 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >4 publications with CDC73 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >3 publications with CDC73 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >132 publications with CDC73 and Parathyroid
 Kidney Antibodies  >26 publications with CDC73 and Kidney
 Blood Antibodies  >20 publications with CDC73 and Blood
 Bone Antibodies  >11 publications with CDC73 and Bone
 Thyroid Antibodies  >10 publications with CDC73 and Thyroid
 Lung Antibodies  >6 publications with CDC73 and Lung
 Vascular Antibodies  >5 publications with CDC73 and Vascular
 Muscle Antibodies  >5 publications with CDC73 and Muscle
 Lymph Node Antibodies  >4 publications with CDC73 and Lymph Node
 Lymph Antibodies  >4 publications with CDC73 and Lymph
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions