BC117182
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
189,071 Da
NCBI Official Full Name
Homo sapiens centrosomal protein 152kDa, mRNA
NCBI Official Synonym Full Names
centrosomal protein 152
NCBI Protein Information
centrosomal protein of 152 kDa
UniProt Protein Name
Centrosomal protein of 152 kDa
UniProt Synonym Gene Names
UniProt Entry Name
CE152_HUMAN
NCBI Summary for CEP152
This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
UniProt Comments for CEP152
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).
Research Articles on CEP152
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Pathways associated with CEP152 cdna clone
Diseases associated with CEP152 cdna clone
Organs/Tissues associated with CEP152 cdna clone
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