BC071844
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,837 Da
NCBI Official Full Name
Homo sapiens claudin 7, mRNA
NCBI Official Synonym Full Names
claudin 7
NCBI Official Synonym Symbols
CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1 [Similar Products]
NCBI Protein Information
claudin-7
UniProt Protein Name
Claudin-7
UniProt Synonym Gene Names
UniProt Entry Name
CLD7_HUMAN
NCBI Summary for CLDN7
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
UniProt Comments for CLDN7
Claudin-7: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: tight junction
Molecular Function: identical protein binding; protein binding
Biological Process: calcium-independent cell-cell adhesion; positive regulation of defense response to virus by host
Research Articles on CLDN7
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Pathways associated with CLDN7 cdna clone
Diseases associated with CLDN7 cdna clone
Organs/Tissues associated with CLDN7 cdna clone
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