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COG5 cdna clone

Scan QR to view Datasheet Catalog #    MBS1273627 COG5 cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

COG5, cDNA Clone

 Also Known As   

COG5 cDNA Clone

 Product Gene Name   

COG5 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    606821
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of COG5 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for COG5. It may not necessarily be applicable to this product.
 NCBI GI #    46249929
 NCBI GeneID    10466
 NCBI Accession #    BC068540 [Other Products]
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 UniProt Secondary Accession #    O14555; O95008; Q6NUL5; A4D0R6; A4D0R7 [Other Products]
 UniProt Related Accession #    Q9UP83 [Other Products]
 Molecular Weight    90,810 Da
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 NCBI Official Full Name    Homo sapiens component of oligomeric golgi complex 5, mRNA
 NCBI Official Synonym Full Names    component of oligomeric golgi complex 5
 NCBI Official Symbol    COG5 [Similar Products]
 NCBI Official Synonym Symbols   
CDG2I; GTC90; GOLTC1
[Similar Products]
 NCBI Protein Information    conserved oligomeric Golgi complex subunit 5
 UniProt Protein Name    Conserved oligomeric Golgi complex subunit 5
 UniProt Synonym Protein Names   
13S Golgi transport complex 90 kDa subunit; GTC-90; Component of oligomeric Golgi complex 5; Golgi transport complex 1
 Protein Family    Conserved oligomeric Golgi complex
 UniProt Gene Name    COG5 [Similar Products]
 UniProt Synonym Gene Names    GOLTC1; GTC90; COG complex subunit 5; GTC-90 [Similar Products]
 UniProt Entry Name    COG5_HUMAN
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 NCBI Summary for COG5    The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]
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 UniProt Comments for COG5    COG5: Required for normal Golgi function. Defects in COG5 are the cause of congenital disorder of glycosylation type 2I (CDG2I). A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Congenital disorder of glycosylation type 2I is characterized by mild neurological impairments. Belongs to the COG5 family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: Golgi apparatus; Golgi membrane; Golgi transport complex; membrane; nucleoplasm; trans-Golgi network membrane

Molecular Function: protein binding

Biological Process: ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport

Disease: Congenital Disorder Of Glycosylation, Type Iii
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 Research Articles on COG5    1. Targeted silencing of components of lobe B of the COG complex, namely COG5, COG6, COG7 and COG8, inhibited HIV-1 replication
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with COG5 cdna cloneOrgans/Tissues associated with COG5 cdna clone
 Disease Name  Pubmed Publications
 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIi Antibodies  >1 publications with COG5 and CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIi
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with COG5 and Liver
 Blood Antibodies  >2 publications with COG5 and Blood
 Bone Antibodies  >1 publications with COG5 and Bone
 Connective Tissue Antibodies  >1 publications with COG5 and Connective Tissue
 Heart Antibodies  >1 publications with COG5 and Heart
 Skin Antibodies  >1 publications with COG5 and Skin
 Ovary Antibodies  >1 publications with COG5 and Ovary
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