BC012629
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,405 Da
NCBI Official Full Name
Homo sapiens COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis), mRNA
NCBI Official Synonym Full Names
COP9 signalosome subunit 2
NCBI Protein Information
COP9 signalosome complex subunit 2
UniProt Protein Name
COP9 signalosome complex subunit 2
UniProt Synonym Protein Names
Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15
UniProt Synonym Gene Names
CSN2; TRIP15; SGN2; Signalosome subunit 2; TR-interacting protein 15; TRIP-15 [Similar Products]
UniProt Entry Name
CSN2_HUMAN
UniProt Comments for COPS2
COPS2: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Belongs to the CSN2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component: cytoplasm; nucleoplasm; signalosome
Molecular Function: protein binding
Biological Process: cullin deneddylation; nucleotide-excision repair, DNA damage recognition; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair
Research Articles on COPS2
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Diseases associated with COPS2 cdna clone
Organs/Tissues associated with COPS2 cdna clone
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