BC008704
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,577 Da
NCBI Official Full Name
Homo sapiens cytochrome c oxidase subunit IV isoform 1, mRNA
NCBI Official Synonym Full Names
cytochrome c oxidase subunit 4I1
NCBI Official Synonym Symbols
COX4; COXIV; COX4-1; COXIV-1; COX IV-1 [Similar Products]
NCBI Protein Information
cytochrome c oxidase subunit 4 isoform 1, mitochondrial
UniProt Protein Name
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
UniProt Synonym Protein Names
Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit IV isoform 1; COX IV-1
UniProt Synonym Gene Names
UniProt Entry Name
COX41_HUMAN
NCBI Summary for COX4I1
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
UniProt Comments for COX4I1
COX4I1: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Ubiquitous. Belongs to the cytochrome c oxidase IV family.
Protein type: Oxidoreductase; EC 1.9.3.1; Mitochondrial; Membrane protein, integral; Energy Metabolism - oxidative phosphorylation
Chromosomal Location of Human Ortholog: 16q24.1
Cellular Component: membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex IV; mitochondrion; nucleus
Molecular Function: protein binding
Biological Process: generation of precursor metabolites and energy; mitochondrial electron transport, cytochrome c to oxygen
Research Articles on COX4I1
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Pathways associated with COX4I1 cdna clone
Diseases associated with COX4I1 cdna clone
Organs/Tissues associated with COX4I1 cdna clone
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