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CRADD cdna clone

Scan QR to view Datasheet Catalog #    MBS1270640 CRADD cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   


 Product Gene Name   

CRADD cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggaggcca gagacaaaca agtactccgc tcacttcgcc tggagctggg tgcagaggta ttggtggagg gactggttct tcagtacctc taccaggaag gaatcttgac ggaaaaccat attcaagaaa tcaatgctca aaccacaggc ctccggaaaa caatgctcct gctggatatc ctaccttcca ggggccctaa agcatttgat acattcctag attccctaca ggagtttccc tgggtcaggg agaagctgaa gaaggcaagg gaagaggcca tgaccgacct gcctgcaggt gacagattga ctgggatccc ctcgcacatc ctcaacagct ccccatcaga ccggcagatt aaccagctgg cccagaggct gggccctgag tgggagccca tggtgctgtc tctgggactg tcccagacgg atatctaccg ctgtaaggcc aaccaccccc acaacgtgca gtcgcaggtg gtggaggcct tcatccgttg gcggcagcgc ttcgggaagc aggccacctt ccagagcctg cacaacgggc tgcgggctgt ggaggtggac ccctcgctgc tcctgcacat gttggagtga
 OMIM    603454
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CRADD cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for CRADD. It may not necessarily be applicable to this product.
 NCBI GI #    16877580
 NCBI GeneID    8738
 NCBI Accession #    BC017042 [Other Products]
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 UniProt Secondary Accession #    B7Z2Q5 [Other Products]
 UniProt Related Accession #    P78560 [Other Products]
 Molecular Weight    11,826 Da
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 NCBI Official Full Name    Homo sapiens CASP2 and RIPK1 domain containing adaptor with death domain, mRNA
 NCBI Official Synonym Full Names    CASP2 and RIPK1 domain containing adaptor with death domain
 NCBI Official Symbol    CRADD [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    death domain-containing protein CRADD
 UniProt Protein Name    Death domain-containing protein CRADD
 UniProt Synonym Protein Names   
Caspase and RIP adapter with death domain; RIP-associated protein with a death domain
 Protein Family    Death domain-containing protein
 UniProt Gene Name    CRADD [Similar Products]
 UniProt Synonym Gene Names    RAIDD [Similar Products]
 UniProt Entry Name    CRADD_HUMAN
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 NCBI Summary for CRADD    This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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 UniProt Comments for CRADD    CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.

Protein type: Adaptor/scaffold; Apoptosis

Chromosomal Location of Human Ortholog: 12q21.33-q23.1

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protease binding; protein binding; protein binding, bridging

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; induction of apoptosis via death domain receptors; regulation of apoptosis

Disease: Mental Retardation, Autosomal Recessive 34
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 Research Articles on CRADD    1. define a novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CRADD cdna cloneDiseases associated with CRADD cdna clone
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 HIV-1 Nef: Negative Effector Of Fas And TNF-alpha Pathway antibodies  HIV-1 Nef: Negative Effector Of Fas And TNF-alpha Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with CRADD and Neoplasms
 Necrosis Antibodies  >10 publications with CRADD and Necrosis
 Brain Diseases Antibodies  >3 publications with CRADD and Brain Diseases
 Carcinoma, Squamous Cell Antibodies  >3 publications with CRADD and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >2 publications with CRADD and Adenocarcinoma
 Inflammation Antibodies  >2 publications with CRADD and Inflammation
 Drug Toxicity Antibodies  >1 publications with CRADD and Drug Toxicity
 Liver Diseases Antibodies  >1 publications with CRADD and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with CRADD and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >1 publications with CRADD and Liver Neoplasms
Organs/Tissues associated with CRADD cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with CRADD and Blood
 Kidney Antibodies  >3 publications with CRADD and Kidney
 Brain Antibodies  >3 publications with CRADD and Brain
 Embryonic Tissue Antibodies  >2 publications with CRADD and Embryonic Tissue
 Liver Antibodies  >1 publications with CRADD and Liver
 Bone Antibodies  >1 publications with CRADD and Bone
 Prostate Antibodies  >1 publications with CRADD and Prostate
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