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CSNK1E cdna clone

Scan QR to view Datasheet Catalog #    MBS1276843 CSNK1E cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CSNK1E, cDNA Clone

★Popular Item★
 Also Known As   

CSNK1E cDNA Clone

 Product Gene Name   

CSNK1E cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggagctac gtgtggggaa caagtaccgc ctgggacgga agatcgggag cgggtccttc ggagatatct acctgggtgc caacatcgcc tctggtgagg aagtcgccat caagctggag tgtgtgaaga caaagcaccc ccagctgcac atcgagagca agttctacaa gatgatgcag ggtggcgtgg ggatcccgtc catcaagtgg tgcggagctg agggcgacta caacgtgatg gtcatggagc tgctggggcc tagcctcgag gacctgttca acttctgttc ccgcaaattc agcctcaaga cggtgctgct cttggccgac cagatgatca gccgcatcga gtatatccac tccaagaact tcatccaccg ggacgtcaag cccgacaact tcctcatggg gctggggaag aagggcaacc tggtctacat catcgacttc ggcctggcca agaagtaccg ggacgcccgc acccaccagc acattcccta ccgggaaaac aagaacctga ccggcacggc ccgctacgct tccatcaaca cgcacctggg cattgagcaa agccgtcgag atgacctgga gagcctgggc tacgtgctca tgtacttcaa cctgggctcc ctgccctggc aggggctcaa agcagccacc aagcgccaga agtatgaacg gatcagcgag aagaagatgt caacgcccat cgaggtcctc tgcaaaggct atccctccga attctcaaca tacctcaact tctgccgctc cctgcggttt gacgacaagc ccgactactc ttacctacgt cagctcttcc gcaacctctt ccaccggcag ggcttctcct atgactacgt ctttgactgg aacatgctga aattcggtgc agcccggaat cccgaggatg tggaccggga gcggcgagaa cacgaacgcg aggagaggat ggggcagcta cgggggtccg cgacccgagc cctgccccct ggcccaccca cgggggccac tgccaaccgg ctccgcagtg ccgccgagcc cgtggcttcc acgccagcct cccgcatcca gccggctggc aatacttctc ccagagcgat ctcgcgggtc gaccgggaga ggaaggtgag tatgaggctg cacaggggtg cgcccgccaa cgtctcctcc tcagacctca ctgggcggca agaggtctcc cggatcccag cctcacagac aagtgtgcca tttgaccatc tcgggaagtg a
 OMIM    600863
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CSNK1E cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for CSNK1E. It may not necessarily be applicable to this product.
 NCBI GI #    33873527
 NCBI GeneID    1454
 NCBI Accession #    BC006490 [Other Products]
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 UniProt Related Accession #    P49674 [Other Products]
 Molecular Weight    47,315 Da
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 NCBI Official Full Name    Homo sapiens casein kinase 1, epsilon, mRNA
 NCBI Official Synonym Full Names    casein kinase 1 epsilon
 NCBI Official Symbol    CSNK1E [Similar Products]
 NCBI Official Synonym Symbols   
HCKIE; CKIepsilon
[Similar Products]
 NCBI Protein Information    casein kinase I isoform epsilon
 UniProt Protein Name    Casein kinase I isoform epsilon
 Protein Family    Casein kinase
 UniProt Gene Name    CSNK1E [Similar Products]
 UniProt Synonym Gene Names    CKI-epsilon; CKIe [Similar Products]
 UniProt Entry Name    KC1E_HUMAN
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 NCBI Summary for CSNK1E    The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
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 UniProt Comments for CSNK1E    CK1E: an ubiquitous protein kinase of the CK1 family. Together with Dvl-1 and Frat-1 activate the Wnt signaling pathway. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. May play a role in cell cycle progression. Two splice variant isoforms have been described. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CK1-D and/or CK1-E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with SOCS3. Mutations in hamster and Drosophila orthologs have circadian rhythm phenotypes, and the circadian gene period (per) is a substrate in both human and fly. A coding SNP variant in human, which increases CK1 activity, is negatively associated with circadian disorder. LOF mutations and LOH seen in mammary ductal carcinoma.

Protein type: EC 2.7.11.1; Protein kinase, CK1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: circadian regulation of gene expression; DNA repair; endocytosis; G2/M transition of mitotic cell cycle; negative regulation of protein binding; peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of cell shape; regulation of circadian rhythm; rRNA processing; signal transduction; Wnt receptor signaling pathway
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 Research Articles on CSNK1E    1. Findings establish CK1varepsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1varepsilon-mediated phosphorylation of TRAF3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CSNK1E cdna cloneDiseases associated with CSNK1E cdna clone
 Products by Pathway  Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 FoxO Family Signaling Pathway antibodies  FoxO Family Signaling Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with CSNK1E and Neoplasms
 Prostatic Diseases Antibodies  >3 publications with CSNK1E and Prostatic Diseases
 Nervous System Diseases Antibodies  >3 publications with CSNK1E and Nervous System Diseases
 Breast Neoplasms Antibodies  >2 publications with CSNK1E and Breast Neoplasms
 Insulin Resistance Antibodies  >1 publications with CSNK1E and Insulin Resistance
 Kidney Neoplasms Antibodies  >1 publications with CSNK1E and Kidney Neoplasms
 Brain Diseases Antibodies  >1 publications with CSNK1E and Brain Diseases
 Liver Neoplasms Antibodies  >1 publications with CSNK1E and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with CSNK1E and Kidney Diseases
Organs/Tissues associated with CSNK1E cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with CSNK1E and Brain
 Blood Antibodies  >4 publications with CSNK1E and Blood
 Liver Antibodies  >3 publications with CSNK1E and Liver
 Prostate Antibodies  >3 publications with CSNK1E and Prostate
 Nerve Antibodies  >2 publications with CSNK1E and Nerve
 Vascular Antibodies  >1 publications with CSNK1E and Vascular
 Stomach Antibodies  >1 publications with CSNK1E and Stomach
 Kidney Antibodies  >1 publications with CSNK1E and Kidney
 Skin Antibodies  >1 publications with CSNK1E and Skin
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