BC006490
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UniProt Related Accession #
Molecular Weight
47,315 Da
NCBI Official Full Name
Homo sapiens casein kinase 1, epsilon, mRNA
NCBI Official Synonym Full Names
casein kinase 1 epsilon
NCBI Protein Information
casein kinase I isoform epsilon
UniProt Protein Name
Casein kinase I isoform epsilon
UniProt Synonym Gene Names
UniProt Entry Name
KC1E_HUMAN
NCBI Summary for CSNK1E
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
UniProt Comments for CSNK1E
CK1E: an ubiquitous protein kinase of the CK1 family. Together with Dvl-1 and Frat-1 activate the Wnt signaling pathway. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. May play a role in cell cycle progression. Two splice variant isoforms have been described. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CK1-D and/or CK1-E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with SOCS3. Mutations in hamster and Drosophila orthologs have circadian rhythm phenotypes, and the circadian gene period (per) is a substrate in both human and fly. A coding SNP variant in human, which increases CK1 activity, is negatively associated with circadian disorder. LOF mutations and LOH seen in mammary ductal carcinoma.
Protein type: EC 2.7.11.1; Protein kinase, CK1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CK1 group; CK1 family
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: circadian regulation of gene expression; DNA repair; endocytosis; G2/M transition of mitotic cell cycle; negative regulation of protein binding; peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of cell shape; regulation of circadian rhythm; rRNA processing; signal transduction; Wnt receptor signaling pathway
Research Articles on CSNK1E
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Pathways associated with CSNK1E cdna clone
Diseases associated with CSNK1E cdna clone
Organs/Tissues associated with CSNK1E cdna clone
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