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CYP11A1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1269283 CYP11A1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $285 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP11A1, cDNA Clone

★Popular Item★
 Also Known As   

CYP11A1 cDNA Clone

 Product Gene Name   

CYP11A1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgctggcca agggtcttcc cccacgctca gtcctggtca aaggctgcca gacctttctg agtgccccca gggaggggct ggggcgtctc agggtgccca ctggcgaggg agctggcatc tccacccgca gtcctcgccc cttcaatgag atcccctctc ctggtgacaa tggctggcta aacctgtacc atttctggag ggagacgggc acacacaaag tccaccttca ccatgtccag aatttccaga agtatggccc gatttacagg gagaagctcg gcaacgtgga gtcggtttat gtcatcgacc ctgaagatgt ggcccttctc tttaagtccg agggccccaa cccagaacga ttcctcatcc cgccctgggt cgcctatcac cagtattacc agagacccat aggagtcctg ttgaagaagt cggcagcctg gaagaaagac cgggtggccc tgaaccagga ggtgatggct ccagaggcca ccaagaactt tttgcccctg ttggatgcag tgtctcggga cttcgtcagt gtcctgcaca ggcgcatcaa gaaggcgggc tccggaaatt actcggggga catcagtgat gacctgttcc gctttgcctt tgagtccatc actaacgtca tttttgggga gcgccagggg atgctggagg aagtagtgaa ccccgaggcc cagcgattca ttgatgccat ctaccagatg ttccacacca gcgtccccat gctcaacctt cccccagacc tgttccgtct gttcaggacc aagacctgga aggaccatgt ggctgcatgg gacgtgattt tcagtaaagc tgacatatac acccagaact tctactggga attgagacag aaaggaagtg ttcaccacga ttaccgtggc atcctctaca gactcctggg agacagcaag atgtccttcg aggacatcaa ggccaacgtc acagagatgc tggcaggagg ggtggacacg acgtccatga ccctgcagtg gcacttgtat gagatggcac gcaacctgaa ggtgcaggat atgctgcggg cagaggtctt ggctgcgcgg caccaggccc agggagacat ggccacgatg ctacagctgg tccccctcct caaagccagc atcaaggaga cactaagact tcaccccatc tccgtgaccc tgcagagata tcttgtaaat gacttggttc ttcgagatta catgattcct gccaagacac tggtgcaagt ggccatctat gctctgggcc gagagcccac cttcttcttc gacccggaaa attttgaccc aacccgatgg ctgagcaaag acaagaacat cacctacttc cggaacttgg gctttggctg gggtgtgcgg cagtgtctgg gacggcggat cgctgagcta gagatgacca tcttcctcat caatatgctg gagaacttca gagttgaaat ccaacacctc agcgatgtgg gcaccacatt caacctcatt ctgatgcctg aaaagcccat ctccttcacc ttctggccct ttaaccagga agcaacccag cagtga
 OMIM    118485
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CYP11A1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for CYP11A1. It may not necessarily be applicable to this product.
 NCBI GI #    21619043
 NCBI GeneID    1583
 NCBI Accession #    BC032329 [Other Products]
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 UniProt Secondary Accession #    Q15081; Q16805; Q8N1A7; A8K8D5; B3KPU8; G3XAD7 [Other Products]
 UniProt Related Accession #    P05108 [Other Products]
 Molecular Weight    42,152 Da
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 NCBI Official Full Name    Homo sapiens cytochrome P450, family 11, subfamily A, polypeptide 1, mRNA
 NCBI Official Synonym Full Names    cytochrome P450 family 11 subfamily A member 1
 NCBI Official Symbol    CYP11A1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    cholesterol side-chain cleavage enzyme, mitochondrial
 UniProt Protein Name    Cholesterol side-chain cleavage enzyme, mitochondrial
 UniProt Synonym Protein Names   
CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc)
 Protein Family    Cholesterol side-chain cleavage enzyme
 UniProt Gene Name    CYP11A1 [Similar Products]
 UniProt Synonym Gene Names    CYP11A [Similar Products]
 UniProt Entry Name    CP11A_HUMAN
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 NCBI Summary for CYP11A1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP11A1    CYP11A1: Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. Defects in CYP11A1 are the cause of adrenal insufficiency congenital with 46,XY sex reversal (AICSR). A rare disorder that can present as acute adrenal insufficiency in infancy or childhood. ACTH and plasma renin activity are elevated and adrenal steroids are inappropriately low or absent; the 46,XY patients have female external genitalia, sometimes with clitoromegaly. The phenotypic spectrum ranges from prematurity, complete underandrogenization, and severe early-onset adrenal failure to term birth with clitoromegaly and later-onset adrenal failure. Patients with congenital adrenal insufficiency do not manifest the massive adrenal enlargement typical of congenital lipoid adrenal hyperplasia. Belongs to the cytochrome P450 family.

Protein type: Lipid Metabolism - C21-steroid hormone; EC; Oxidoreductase; Mitochondrial

Chromosomal Location of Human Ortholog: 15q23-q24

Cellular Component: mitochondrial inner membrane; mitochondrial matrix; mitochondrion

Molecular Function: cholesterol monooxygenase (side-chain-cleaving) activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

Biological Process: C21-steroid hormone biosynthetic process; cholesterol metabolic process; glucocorticoid biosynthetic process; sterol metabolic process; vitamin D metabolic process

Disease: Adrenal Insufficiency, Congenital, With 46,xy Sex Reversal, Partial Or Complete
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 Research Articles on CYP11A1    1. An epistatic effect between CYP11A1 and VDR polymorphisms may contribute to the predisposition to childhood asthma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CYP11A1 cdna cloneDiseases associated with CYP11A1 cdna clone
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 Glucocorticoid & Mineralcorticoid Metabolism Pathway antibodies  Glucocorticoid & Mineralcorticoid Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >225 publications with CYP11A1 and Neoplasms
 Drug Toxicity Antibodies  >127 publications with CYP11A1 and Drug Toxicity
 Hyperplasia Antibodies  >92 publications with CYP11A1 and Hyperplasia
 Congenital Abnormalities Antibodies  >80 publications with CYP11A1 and Congenital Abnormalities
 Disorders of Sex Development Antibodies  >78 publications with CYP11A1 and Disorders of Sex Development
 Urogenital Abnormalities Antibodies  >77 publications with CYP11A1 and Urogenital Abnormalities
 Genital Diseases, Male Antibodies  >63 publications with CYP11A1 and Genital Diseases, Male
 Testicular Diseases Antibodies  >48 publications with CYP11A1 and Testicular Diseases
 Adrenal Insufficiency Antibodies  >45 publications with CYP11A1 and Adrenal Insufficiency
 Hypertension Antibodies  >29 publications with CYP11A1 and Hypertension
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