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CYP21A2 cdna clone

Scan QR to view Datasheet Catalog #    MBS1266684 CYP21A2 cdna clone
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP21A2, cDNA Clone

 Also Known As   

CYP21A2 cDNA Clone

 Product Gene Name   

CYP21A2 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    201910
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CYP21A2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for CYP21A2. It may not necessarily be applicable to this product.
 NCBI GI #    115528434
 NCBI GeneID    1589
 NCBI Accession #    BC125181 [Other Products]
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 UniProt Secondary Accession #    P04033; Q01204; Q08AG8; Q16749; Q16806; Q5ST44; Q96NU8; A2BHY6 [Other Products]
 UniProt Related Accession #    P08686 [Other Products]
 Molecular Weight    52,597 Da
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 NCBI Official Full Name    Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2, mRNA
 NCBI Official Synonym Full Names    cytochrome P450 family 21 subfamily A member 2
 NCBI Official Symbol    CYP21A2 [Similar Products]
 NCBI Official Synonym Symbols   
CAH1; CPS1; CA21H; CYP21; CYP21B; P450c21B
[Similar Products]
 NCBI Protein Information    steroid 21-hydroxylase
 UniProt Protein Name    Steroid 21-hydroxylase
 UniProt Synonym Protein Names   
21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21; Cytochrome P450-C21B
 UniProt Gene Name    CYP21A2 [Similar Products]
 UniProt Synonym Gene Names    CYP21; CYP21B [Similar Products]
 UniProt Entry Name    CP21A_HUMAN
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 NCBI Summary for CYP21A2    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP21A2    CYP21A2: Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. Defects in CYP21A2 are the cause of adrenal hyperplasia type 3 (AH3). AH3 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late onset (NC or LOAH), and 'cryptic' (asymptomatic). Belongs to the cytochrome P450 family.

Protein type: Oxidoreductase; Lipid Metabolism - C21-steroid hormone; EC 1.14.99.10

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: endoplasmic reticulum membrane

Molecular Function: heme binding; steroid 21-monooxygenase activity; steroid hydroxylase activity

Biological Process: glucocorticoid biosynthetic process; mineralocorticoid biosynthetic process; steroid biosynthetic process; steroid metabolic process; sterol metabolic process

Disease: Adrenal Hyperplasia, Congenital, Due To 21-hydroxylase Deficiency
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 Research Articles on CYP21A2    1. The results suggest that the A>G variation in the Z promoter is involved in misregulating the transcriptional activity of the CYP21A2 gene.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CYP21A2 cdna cloneDiseases associated with CYP21A2 cdna clone
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 Glucocorticoid & Mineralcorticoid Metabolism Pathway antibodies  Glucocorticoid & Mineralcorticoid Metabolism Pathway Diagram
 Glucocorticoid Biosynthesis Pathway antibodies  Glucocorticoid Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >232 publications with CYP21A2 and Hyperplasia
 Adrenal Hyperplasia, Congenital Antibodies  >230 publications with CYP21A2 and Adrenal Hyperplasia, Congenital
 Congenital Abnormalities Antibodies  >208 publications with CYP21A2 and Congenital Abnormalities
 Endocrine System Diseases Antibodies  >207 publications with CYP21A2 and Endocrine System Diseases
 Urogenital Abnormalities Antibodies  >202 publications with CYP21A2 and Urogenital Abnormalities
 Congenital adrenal hyperplasia due to 21 hydroxylase deficiency Antibodies  >43 publications with CYP21A2 and Congenital adrenal hyperplasia due to 21 hydroxylase deficiency
 Adrenal Gland Neoplasms Antibodies  >8 publications with CYP21A2 and Adrenal Gland Neoplasms
 Infertility, Male Antibodies  >8 publications with CYP21A2 and Infertility, Male
 Pregnancy Complications Antibodies  >8 publications with CYP21A2 and Pregnancy Complications
 Nervous System Diseases Antibodies  >7 publications with CYP21A2 and Nervous System Diseases
Organs/Tissues associated with CYP21A2 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Adrenal Gland Antibodies  >30 publications with CYP21A2 and Adrenal Gland
 Liver Antibodies  >8 publications with CYP21A2 and Liver
 Brain Antibodies  >7 publications with CYP21A2 and Brain
 Ovary Antibodies  >6 publications with CYP21A2 and Ovary
 Testis Antibodies  >5 publications with CYP21A2 and Testis
 Heart Antibodies  >4 publications with CYP21A2 and Heart
 Muscle Antibodies  >2 publications with CYP21A2 and Muscle
 Eye Antibodies  >1 publications with CYP21A2 and Eye
 Spleen Antibodies  >1 publications with CYP21A2 and Spleen
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