BC067445
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,950 Da
NCBI Official Full Name
Homo sapiens disabled homolog 1 (Drosophila), mRNA
NCBI Official Synonym Full Names
DAB1, reelin adaptor protein
NCBI Protein Information
disabled homolog 1
UniProt Protein Name
Disabled homolog 1
UniProt Entry Name
DAB1_HUMAN
NCBI Summary for DAB1
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for DAB1
DAB1: an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p32-p31
Cellular Component: intracellular membrane-bound organelle; microtubule organizing center; nucleolus
Molecular Function: protein binding
Research Articles on DAB1
Precautions
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Pathways associated with DAB1 cdna clone
Diseases associated with DAB1 cdna clone
Organs/Tissues associated with DAB1 cdna clone
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