BC000283
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
76,300 Da
NCBI Official Full Name
Homo sapiens drebrin 1, mRNA
NCBI Official Synonym Full Names
drebrin 1
NCBI Official Synonym Symbols
NCBI Protein Information
drebrin
UniProt Protein Name
Drebrin
UniProt Synonym Protein Names
Developmentally-regulated brain protein
UniProt Synonym Gene Names
UniProt Entry Name
DREB_HUMAN
NCBI Summary for DBN1
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DBN1
DBN1: a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. Expressed in brain neurons, heart, placenta, skeletal muscle, kidney and pancreas. Two alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Actin-binding
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: actin cytoskeleton; cell-cell adherens junction; growth cone; plasma membrane
Molecular Function: profilin binding; protein binding
Biological Process: actin filament organization
Research Articles on DBN1
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Diseases associated with DBN1 cdna clone
Organs/Tissues associated with DBN1 cdna clone
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