BC062682
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
8,295 Da
NCBI Official Full Name
Homo sapiens dermcidin, mRNA
NCBI Official Synonym Full Names
dermcidin
NCBI Protein Information
dermcidin
UniProt Protein Name
Dermcidin
UniProt Synonym Protein Names
Preproteolysin
UniProt Synonym Gene Names
UniProt Entry Name
DCD_HUMAN
NCBI Summary for DCD
This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
UniProt Comments for DCD
DCD: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; EC 3.4.-.-; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12q13.1
Cellular Component: extracellular matrix; extracellular region
Molecular Function: protein binding
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Diseases associated with DCD cdna clone
Organs/Tissues associated with DCD cdna clone
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