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DEF6 cdna clone

Scan QR to view Datasheet Catalog #    MBS1270657 DEF6 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DEF6, cDNA Clone

★Popular Item★
 Also Known As   

DEF6 cDNA Clone

 Product Gene Name   

DEF6 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggccctgc gcaaggaact gctcaagtcc atctggtacg cctttaccgc gctggacgtg gagaagagtg gcaaagtctc caagtcccag ctcaaggtgc tgtcccacaa cctgtacacg gtcctgcaca tcccccatga ccccgtggcc ctggaggaac acttccgaga tgatgatgac ggccctgtgt ccagccaggg atacatgccc tacctcaaca agtacatcct ggacaaggtg gaggaggggg cttttgttaa agagcacttt gatgagctgt gctggacgct gacggccaag aagaactatc gggcagatag caacgggaac agtatgctct ccaatcagga tgccttccgc ctctggtgcc tcttcaactt cctgtctgag gacaagtacc ctctgatcat ggttcctgat gaggtggaat acctgctgaa aaaggtactc agcagcatga gcttggaggt gagcttgggt gagctggagg agcttctggc ccaggaggcc caggtggccc agaccaccgg ggggctcagc gtctggcagt tcctggagct cttcaattcg ggccgctgcc tgcggggcgt gggccgggac accctcagca tggccatcca cgaggtctac caggagctca tccaagatgt cctgaagcag ggctacctgt ggaagcgagg gcacctgaga aggaactggg ccgaacgctg gttccagctg cagcccagct gcctctgcta ctttgggagt gaagagtgca aagagaaaag gggcattatc ccgctggatg cacactgctg cgtggaggtg ctgccagacc gcgacggaaa gcgctgcatg ttctgtgtga agacagccac ccgcacgtat gagatgagcg cctcagacac gcgccagcgc caggagtgga cagctgccat ccagatggcg atccggctgc aggccgaggg gaagacgtcc ctacacaagg acctgaagca gaaacggcgc gagcagcggg agcagcggta g
 OMIM    610094
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of DEF6 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for DEF6. It may not necessarily be applicable to this product.
 NCBI GI #    17028384
 NCBI GeneID    50619
 NCBI Accession #    BC017504 [Other Products]
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 UniProt Secondary Accession #    Q86VF4 [Other Products]
 UniProt Related Accession #    Q9H4E7 [Other Products]
 Molecular Weight    73,910 Da
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 NCBI Official Full Name    Homo sapiens differentially expressed in FDCP 6 homolog (mouse), mRNA
 NCBI Official Synonym Full Names    DEF6, guanine nucleotide exchange factor
 NCBI Official Symbol    DEF6 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    differentially expressed in FDCP 6 homolog
 UniProt Protein Name    Differentially expressed in FDCP 6 homolog
 UniProt Synonym Protein Names   
IRF4-binding protein
 Protein Family    Differentially expressed in FDCP
 UniProt Gene Name    DEF6 [Similar Products]
 UniProt Synonym Gene Names    IBP; DEF-6 [Similar Products]
 UniProt Entry Name    DEFI6_HUMAN
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 NCBI Summary for DEF6    DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for DEF6    DEF6: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling.

Protein type: GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 6p21.33-p21.1

Cellular Component: membrane

Molecular Function: protein binding
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 Research Articles on DEF6    1. IBP was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with DEF6 cdna cloneDiseases associated with DEF6 cdna clone
 Products by Pathway  Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with DEF6 and Neoplasms
 Inflammation Antibodies  >5 publications with DEF6 and Inflammation
 Disease Models, Animal Antibodies  >4 publications with DEF6 and Disease Models, Animal
 Brain Diseases Antibodies  >2 publications with DEF6 and Brain Diseases
 Nervous System Diseases Antibodies  >2 publications with DEF6 and Nervous System Diseases
 Leukemia Antibodies  >1 publications with DEF6 and Leukemia
 Lymphoma Antibodies  >1 publications with DEF6 and Lymphoma
Organs/Tissues associated with DEF6 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with DEF6 and Blood
 Intestine Antibodies  >1 publications with DEF6 and Intestine
 Bone Antibodies  >1 publications with DEF6 and Bone
 Pharynx Antibodies  >1 publications with DEF6 and Pharynx
 Bone Marrow Antibodies  >1 publications with DEF6 and Bone Marrow
 Eye Antibodies  >1 publications with DEF6 and Eye
 Tonsil Antibodies  >1 publications with DEF6 and Tonsil
 Mouth Antibodies  >1 publications with DEF6 and Mouth
 Lymph Node Antibodies  >1 publications with DEF6 and Lymph Node
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