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DHCR24 cdna clone

Scan QR to view Datasheet Catalog #    MBS1275641 DHCR24 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $285 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DHCR24, cDNA Clone

 Also Known As   

DHCR24 cDNA Clone

 Product Gene Name   

DHCR24 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggagcccg ccgtgtcgct ggccgtgtgc gcgctgctct tcctgctgtg ggtgcgcctg aaggggctgg agttcgtgct catccaccag cgctgggtgt tcgtgtgcct cttcctcctg ccgctctcgc ttatcttcga tatctactac tacgtgcgcg cctgggtggt gttcaagctc agcagcgctc cgcgcctgca cgagcagcgc gtgcgggaca tccagaagca ggtgcgggaa tggaaggagc agggtagcaa gaccttcatg tgcacggggc gccctggctg gctcactgtc tcactacgtg tcgggaagta caagaagaca cacaaaaaca tcatgatcaa cctgatggac attctggaag tggacaccaa gaaacagatt gtccgtgtgg agcccttggt gaccatgggc caggtgactg ccctgctgac ctccattggc tggactctcc ccgtgttgcc tgagcttgat gacctcacag tggggggctt gatcatgggc acaggcatcg agtcatcatc ccacaagtac ggcctgttcc aacacatctg cactgcttac gagctggtcc tggctgatgg cagctttgtg cgatgcactc cgtccgaaaa ctcagacctg ttctatgccg taccctggtc ctgtgggacg ctgggtttcc tggtggccgc tgagatccgc atcatccctg ccaagaagta cgtcaagctg cgtttcgagc cagtgcgggg cctggaggct atctgtgcca agttcaccca cgagtcccag cggcaggaga accacttcgt ggaagggctg ctctactccc tggatgaggc tgtcattatg acaggggtca tgacagatga ggcagagccc agcaagctga atagcattgg caattactac aagccgtggt tctttaagca tgtggagaac tatctgaaga caaaccgaga gggcctggag tacattccct tgagacacta ctaccaccgc cacacgcgca gcatcttctg ggagctccag gacattatcc cctttggcaa caaccccatc ttccgctacc tctttggctg gatggtgcct cccaagatct ccctcctgaa gctgacccag ggtgagaccc tgcgcaagct gtacgagcag caccacgtgg tgcaggacat gctggtgccc atgaagtgcc tgcagcaggc cctgcacacc ttccaaaacg acatccacgt ctaccccatc tggctgtgtc cgttcatcct gcccagccag ccaggcctag tgcaccccaa aggaaatgag gcagagctct acatcgacat tggagcatat ggggagccgc gtgtgaaaca ctttgaagcc aggtcctgca tgaggcagct ggagaagttt gtccgcagcg tgcatggctt ccagatgctg tatgccgact gctacatgaa ccgggaggag ttctgggaga tgtttgatgg ctccttgtac cacaagctgc gagagaagct gggttgccag gacgccttcc ccgaggtgta cgacaagatc tgcaaggccg ccaggcactg a
 OMIM    602398
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of DHCR24 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for DHCR24. It may not necessarily be applicable to this product.
 NCBI GI #    13325123
 NCBI GeneID    1718
 NCBI Accession #    BC004375 [Other Products]
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 UniProt Secondary Accession #    Q9HBA8; B7Z817; D3DQ51 [Other Products]
 UniProt Related Accession #    Q15392 [Other Products]
 Molecular Weight    54,750 Da
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 NCBI Official Full Name    Homo sapiens 24-dehydrocholesterol reductase, mRNA
 NCBI Official Synonym Full Names    24-dehydrocholesterol reductase
 NCBI Official Symbol    DHCR24 [Similar Products]
 NCBI Official Synonym Symbols   
DCE; SELADIN1; Nbla03646; seladin-1
[Similar Products]
 NCBI Protein Information    delta(24)-sterol reductase
 UniProt Protein Name    Delta(24)-sterol reductase
 UniProt Synonym Protein Names   
24-dehydrocholesterol reductase; 3-beta-hydroxysterol delta-24-reductase; Diminuto/dwarf1 homolog; Seladin-1
 Protein Family    Delta(24)-sterol reductase
 UniProt Gene Name    DHCR24 [Similar Products]
 UniProt Synonym Gene Names    KIAA0018 [Similar Products]
 UniProt Entry Name    DHC24_HUMAN
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 NCBI Summary for DHCR24    This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DHCR24    Diminuto: the enzyme 3-beta-hydroxysterol delta-24-reductase (DHCR24), a member of the flavin adenine dinucleotide (FAD)-dependent oxidoreductases, catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. Overexpressed in the adenoma tissue of patients with Cushing's syndrome. May be involved in the molecular events of adrenocortical tumorigenesis by facilitating steroid synthesis and cell growth.

Protein type: Oxidoreductase; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; EC 1.3.1.72

Chromosomal Location of Human Ortholog: 1p32.3

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane; nucleus

Molecular Function: delta24(24-1) sterol reductase activity; delta24-sterol reductase activity; enzyme binding; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; peptide antigen binding

Biological Process: cholesterol biosynthetic process; cholesterol biosynthetic process via desmosterol; cholesterol biosynthetic process via lathosterol; negative regulation of apoptosis; negative regulation of caspase activity; response to oxidative stress; skin development; tissue development

Disease: Desmosterolosis
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 Research Articles on DHCR24    1. DHCR24 auto-antibody represents a potential noninvasive biomarker for hepatitis C virus-related liver disease and may facilitate the diagnosis of PIVKA-II and AFP-negative hepatocellular carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with DHCR24 cdna cloneDiseases associated with DHCR24 cdna clone
 Products by Pathway  Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Cholesterol Biosynthesis I Pathway antibodies  Cholesterol Biosynthesis I Pathway Diagram
 Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol) Pathway antibodies  Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol) Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >27 publications with DHCR24 and Nervous System Diseases
 Brain Diseases Antibodies  >27 publications with DHCR24 and Brain Diseases
 Neoplasms Antibodies  >18 publications with DHCR24 and Neoplasms
 Desmosterolosis Antibodies  >11 publications with DHCR24 and Desmosterolosis
 Drug Toxicity Antibodies  >8 publications with DHCR24 and Drug Toxicity
 Hepatitis Antibodies  >6 publications with DHCR24 and Hepatitis
 Inflammation Antibodies  >5 publications with DHCR24 and Inflammation
 Liver Diseases Antibodies  >3 publications with DHCR24 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with DHCR24 and Carcinoma, Hepatocellular
 Atherosclerosis Antibodies  >3 publications with DHCR24 and Atherosclerosis
Organs/Tissues associated with DHCR24 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >71 publications with DHCR24 and Nerve
 Brain Antibodies  >37 publications with DHCR24 and Brain
 Liver Antibodies  >13 publications with DHCR24 and Liver
 Blood Antibodies  >13 publications with DHCR24 and Blood
 Prostate Antibodies  >9 publications with DHCR24 and Prostate
 Skin Antibodies  >6 publications with DHCR24 and Skin
 Embryonic Tissue Antibodies  >5 publications with DHCR24 and Embryonic Tissue
 Adrenal Gland Antibodies  >5 publications with DHCR24 and Adrenal Gland
 Vascular Antibodies  >4 publications with DHCR24 and Vascular
 Thyroid Antibodies  >3 publications with DHCR24 and Thyroid
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