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DKK1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1273888 DKK1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DKK1, cDNA Clone

★Popular Item★
 Also Known As   

DKK1 cDNA Clone

 Product Gene Name   

DKK1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgatggctc tgggcgcagc gggagctacc cgggtctttg tcgcgatggt agcggcggct ctcggcggcc accctctgct gggagtgagc gccaccttga actcggttct caattccaac gctatcaaga acctgccccc accgctgggc ggcgctgcgg ggcacccagg ctctgcagtc agcgccgcgc cgggaatcct gtacccgggc gggaataagt accagaccat tgacaactac cagccgtacc cgtgcgcaga ggacgaggag tgcggcactg atgagtactg cgctagtccc acccgcggag gggacgcagg cgtgcaaatc tgtctcgcct gcaggaagcg ccgaaaacgc tgcatgcgtc acgctatgtg ctgccccggg aattactgca aaaatggaat atgtgtgtct tctgatcaaa atcatttccg aggagaaatt gaggaaacca tcactgaaag ctttggtaat gatcatagca ccttggatgg gtattccaga agaaccacct tgtcttcaaa aatgtatcac accaaaggac aagaaggttc tgtttgtctc cggtcatcag actgtgcctc aggattgtgt tgtgctagac acttctggtc caagatctgt aaacctgtcc tgaaagaagg tcaagtgtgt accaagcata ggagaaaagg ctctcatgga ctagaaatat tccagcgttg ttactgtgga gaaggtctgt cttgccggat acagaaagat caccatcaag ccagtaattc ttctaggctt cacacttgtc agagacacta a
 OMIM    605189
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of DKK1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for DKK1. It may not necessarily be applicable to this product.
 NCBI GI #    33878885
 NCBI GeneID    22943
 NCBI Accession #    BC001539 [Other Products]
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 UniProt Secondary Accession #    B2RC19 [Other Products]
 UniProt Related Accession #    O94907 [Other Products]
 Molecular Weight    28,672 Da
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 NCBI Official Full Name    Homo sapiens dickkopf homolog 1 (Xenopus laevis), mRNA
 NCBI Official Synonym Full Names    dickkopf WNT signaling pathway inhibitor 1
 NCBI Official Symbol    DKK1 [Similar Products]
 NCBI Official Synonym Symbols   
SK; DKK-1
[Similar Products]
 NCBI Protein Information    dickkopf-related protein 1
 UniProt Protein Name    Dickkopf-related protein 1
 UniProt Synonym Protein Names   
SK
 Protein Family    Dickkopf-related protein
 UniProt Gene Name    DKK1 [Similar Products]
 UniProt Synonym Gene Names    Dickkopf-1; Dkk-1; hDkk-1 [Similar Products]
 UniProt Entry Name    DKK1_HUMAN
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 NCBI Summary for DKK1    This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DKK1    DKK1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling. Placenta. Belongs to the dickkopf family.

Protein type: Inhibitor; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: early endosome membrane; extracellular region; extracellular space; plasma membrane

Molecular Function: growth factor activity; low-density lipoprotein receptor binding; protein binding; receptor antagonist activity; signal transducer activity

Biological Process: negative regulation of mesodermal cell fate specification; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein binding; negative regulation of synaptogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of Wnt receptor signaling pathway; regulation of endodermal cell fate specification; regulation of receptor internalization
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 Research Articles on DKK1    1. Through expression of the WNT inhibitor DKK1, latency competent cancer cells self-impose a slow-cycling state with broad downregulation of ULBP ligands for NK cells and evasion of NK-cell-mediated clearance.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with DKK1 cdna cloneDiseases associated with DKK1 cdna clone
 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Presenilin Action In Notch And Wnt Signaling Pathway antibodies  Presenilin Action In Notch And Wnt Signaling Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 Wnt Signaling Network Pathway antibodies  Wnt Signaling Network Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >256 publications with DKK1 and Neoplasms
 Cardiovascular Diseases Antibodies  >71 publications with DKK1 and Cardiovascular Diseases
 Hematologic Diseases Antibodies  >61 publications with DKK1 and Hematologic Diseases
 Nervous System Diseases Antibodies  >31 publications with DKK1 and Nervous System Diseases
 Brain Diseases Antibodies  >29 publications with DKK1 and Brain Diseases
 Breast Neoplasms Antibodies  >29 publications with DKK1 and Breast Neoplasms
 Inflammation Antibodies  >28 publications with DKK1 and Inflammation
 Necrosis Antibodies  >26 publications with DKK1 and Necrosis
 Neoplasm Metastasis Antibodies  >23 publications with DKK1 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >20 publications with DKK1 and Kidney Diseases
Organs/Tissues associated with DKK1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >368 publications with DKK1 and Bone
 Embryonic Tissue Antibodies  >89 publications with DKK1 and Embryonic Tissue
 Bone Marrow Antibodies  >79 publications with DKK1 and Bone Marrow
 Brain Antibodies  >66 publications with DKK1 and Brain
 Connective Tissue Antibodies  >61 publications with DKK1 and Connective Tissue
 Vascular Antibodies  >43 publications with DKK1 and Vascular
 Skin Antibodies  >37 publications with DKK1 and Skin
 Liver Antibodies  >35 publications with DKK1 and Liver
 Muscle Antibodies  >31 publications with DKK1 and Muscle
 Uterus Antibodies  >28 publications with DKK1 and Uterus
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