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DTL cdna clone

Scan QR to view Datasheet Catalog #    MBS1270451 DTL cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DTL, cDNA Clone

★Popular Item★
 Also Known As   

DTL cDNA Clone

 Product Gene Name   

DTL cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgctcttca attcggtgct ccgccagccc cagcttggcg tcctgagaaa tggatggtct tcacaatacc ctcttcaatc ccttctgact ggttatcagt gcagtggtaa tgatgaacac acttcttatg gagaaacagg agtcccagtt cctccttttg gatgtacctt ctcttctgct cccaatatgg aacatgtact agcagttgcc aatgaagaag gctttgttcg attgtataac acagaatcac aaagtttcag aaagaagtgc ttcaaagaat ggatggctca ctggaatgcc gtctttgacc tggcctgggt tcctggtgaa cttaaacttg ttacagcagc aggtgatcaa acagccaaat tttgggacgt aaaagctggt gagctgattg gaacatgcaa aggtcatcaa tgcagcctca agtcagttgc cttttctaag tttgagaaag ctgtattctg tacgggtgga agagatggca acattatggt ctgggatacc aggtgcaaca aaaaagatgg gttttatagg caagtgaatc aaatcagtgg agctcacaat acctcagaca agcaaacccc ttcaaaaccc aagaagaaac agaattcaaa aggacttgct ccttctgtgg atttccagca aagtgttact gtggtcctct ttcaagacga gaatacctta gtctcagcag gagctgtgga tgggataatc aaagtatggg atttacgtaa gaattatact gcttatcgac aagaacccat agcatccaag tctttcctgt acccaggtag cagcactcga aaacttggat attcaagtct gattttggat tccactggct ctactttatt tgctaattgc acagacgata acatctacat gtttaatatg actgggttga agacttctcc agtggctatt ttcaatggac accagaactc taccttttat gtaaaatcca gccttagtcc agatgaccag tttttagtca gtggctcaag tgatgaagct gcctacatat ggaaggtctc cacaccctgg caacctccta ctgtgctcct gggtcattct caagaggtca cgtctgtgtg ctggtgtcca tctgacttca caaagattgc tacctgttct gatgacaata cactaaaaat ctggcgcttg aatagaggct tagaggagaa accaggaggt gataaacttt ccacggtggg ttgggcctct cagaagaaaa aagagtcaag acctggccta gtaacagtaa cgagtagcca gagtactcct gccaaagccc ccagggtaaa gtgcaatcca tccaattctt ccccgtcatc cgcagcttgt gccccaagct gtgctggaga cctccctctt ccttcaaata ctcctacgtt ctctattaaa acctctcctg ccaaggcccg gtctcccatc aacagaagag gctctgtctc ctccgtctct cccaagccac cttcatcttt caagatgtcg attagaaact gggtgacccg aacaccttcc tcatcaccac ccatcactcc acctgcttcg gagaccaaga tcatgtctcc gagaaaagcc cttattcctg tgagccagaa gtcatcccaa gcagaggctt gctctgagtc tagaaataga gtaaagagga ggctagactc aagctgtctg gagagtgtga aacaaaagtg tgtgaagagt tgtaactgtg tgactgagct tgatggccaa gttgaaaatc ttcatttgga tctgtgctgc cttgctggta accaggaaga ccttagtaag gactctctag gtcctaccaa atcaagcaaa attgaaggag ctggtaccag tatctcagag cctccgtctc ctatcagtcc gtatgcttca gaaagctgtg gaacgctacc tcttcctttg agaccttgtg gagaagggtc tgaaatggta ggcaaagaga atagttcccc agagaataaa aactggttgt tggccatggc agccaaacgg aaggctgaga atccatctcc acgaagtccg tcatcccaga cacccaattc caggagacag agcggaaaga cattgccaag cccggtcacc atcacgccca gctccatgag gaaaatctgc acatacttcc atagaaagtc ccaggaggac ttctgtggtc ctgaacactc aacagaatta tag
 OMIM    610617
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of DTL cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for DTL. It may not necessarily be applicable to this product.
 NCBI GI #    23271027
 NCBI GeneID    51514
 NCBI Accession #    BC033297 [Other Products]
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 UniProt Secondary Accession #    Q5VT77; Q96SN0; Q9NW03; Q9NW34; Q9NWM5; A8K8H8; D3DT98 [Other Products]
 UniProt Related Accession #    Q9NZJ0 [Other Products]
 Molecular Weight    23,682 Da
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 NCBI Official Full Name    Homo sapiens denticleless homolog (Drosophila), mRNA
 NCBI Official Synonym Full Names    denticleless E3 ubiquitin protein ligase homolog
 NCBI Official Symbol    DTL [Similar Products]
 NCBI Official Synonym Symbols   
CDT2; RAMP; DCAF2; L2DTL
[Similar Products]
 NCBI Protein Information    denticleless protein homolog
 UniProt Protein Name    Denticleless protein homolog
 UniProt Synonym Protein Names   
DDB1- and CUL4-associated factor 2; Lethal(2) denticleless protein homolog; Retinoic acid-regulated nuclear matrix-associated protein
 Protein Family    Denticleless protein
 UniProt Gene Name    DTL [Similar Products]
 UniProt Synonym Gene Names    CDT2; CDW1; DCAF2; L2DTL; RAMP [Similar Products]
 UniProt Entry Name    DTL_HUMAN
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 UniProt Comments for DTL    RAMP: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. Belongs to the WD repeat cdt2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: centrosome; cytoplasm; intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: bypass DNA synthesis; DNA damage response, detection of DNA damage; G2/M transition DNA damage checkpoint; protein monoubiquitination; protein polyubiquitination; regulation of cell cycle; response to DNA damage stimulus; response to UV; ubiquitin-dependent protein catabolic process
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 Research Articles on DTL    1. CDT2 mediated XPG elimination from DNA damage sites clears the chromatin space needed for repair.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with DTL cdna cloneOrgans/Tissues associated with DTL cdna clone
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >18 publications with DTL and Neoplasms
 Disease Models, Animal Antibodies  >6 publications with DTL and Disease Models, Animal
 Hypertension Antibodies  >4 publications with DTL and Hypertension
 Adenocarcinoma Antibodies  >4 publications with DTL and Adenocarcinoma
 Liver Diseases Antibodies  >2 publications with DTL and Liver Diseases
 Inflammation Antibodies  >2 publications with DTL and Inflammation
 Kidney Diseases Antibodies  >2 publications with DTL and Kidney Diseases
 Neoplasms, Experimental Antibodies  >2 publications with DTL and Neoplasms, Experimental
 Congenital Abnormalities Antibodies  >2 publications with DTL and Congenital Abnormalities
 Liver Neoplasms Antibodies  >2 publications with DTL and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >52 publications with DTL and Eye
 Kidney Antibodies  >32 publications with DTL and Kidney
 Blood Antibodies  >20 publications with DTL and Blood
 Vascular Antibodies  >14 publications with DTL and Vascular
 Nerve Antibodies  >10 publications with DTL and Nerve
 Skin Antibodies  >9 publications with DTL and Skin
 Heart Antibodies  >6 publications with DTL and Heart
 Bone Antibodies  >4 publications with DTL and Bone
 Brain Antibodies  >4 publications with DTL and Brain
 Lung Antibodies  >3 publications with DTL and Lung
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