BC014068
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
83,496 Da
NCBI Official Full Name
Homo sapiens E4F transcription factor 1, mRNA
NCBI Official Synonym Full Names
E4F transcription factor 1
NCBI Official Synonym Symbols
NCBI Protein Information
transcription factor E4F1
UniProt Protein Name
Transcription factor E4F1
UniProt Synonym Protein Names
E4F transcription factor 1; Putative E3 ubiquitin-protein ligase E4F1; Transcription factor E4F; p120E4F; p50E4F
UniProt Synonym Gene Names
UniProt Entry Name
E4F1_HUMAN
NCBI Summary for E4F1
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]
UniProt Comments for E4F1
E4F1: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.
Protein type: Ligase; DNA-binding; Transcription factor; C2H2-type zinc finger protein; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: nucleoplasm
Molecular Function: DNA binding; protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity
Biological Process: cell proliferation; negative regulation of transcription from RNA polymerase II promoter
Research Articles on E4F1
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Pathways associated with E4F1 cdna clone
Diseases associated with E4F1 cdna clone
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