BC015364
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,396 Da
NCBI Official Full Name
Homo sapiens Epstein-Barr virus induced 3, mRNA
NCBI Official Synonym Full Names
Epstein-Barr virus induced 3
NCBI Protein Information
interleukin-27 subunit beta
UniProt Protein Name
Interleukin-27 subunit beta
UniProt Synonym Protein Names
Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein
UniProt Synonym Gene Names
IL27B; IL-27 subunit beta; IL-27B; EBV-induced gene 3 protein [Similar Products]
UniProt Entry Name
IL27B_HUMAN
NCBI Summary for EBI3
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
UniProt Comments for EBI3
IL27-beta: Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon- gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Belongs to the type I cytokine receptor family. Type 3 subfamily.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: extracellular region; plasma membrane
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding
Biological Process: humoral immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of interferon-gamma biosynthetic process; T-helper 1 type immune response
Research Articles on EBI3
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Pathways associated with EBI3 cdna clone
Diseases associated with EBI3 cdna clone
Organs/Tissues associated with EBI3 cdna clone
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