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ECE2 cdna clone

Scan QR to view Datasheet Catalog #    MBS1266214 ECE2 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ECE2, cDNA Clone

 Also Known As   

ECE2 cDNA Clone

 Product Gene Name   

ECE2 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggcctctc caggggcagg tagggcgcct ccggagttac cggagcggaa ctgcgggtac cgcgaagtcg agtactggga tcagcgctac caaggcgcag ccgattctgc cccctacgat tggttcgggg acttctcctc cttccgtgcc ctcctagagc cggagctgcg gcccgaggac cgtatccttg tgctaggttg cgggaacagt gccctgagct acgagctgtt cctcggaggc ttccctaatg tgaccagtgt ggactactca tcagtcgtgg tggctgccat gcaggctcgc tatgcccatg tgccgcagct gcgctgggag accatggatg tgcggaagct ggacttcccc agtgcttctt ttgatgtggt gctcgagaag ggcacgctgg atgccctgct ggctggggaa cgagatccct ggaccgtgtc ctctgaaggt gtccacactg tggaccaggt gttgagtgag gtgagccgcg tgcttgtccc tggaggccgg tttatctcaa tgacttctgc tgccccccac tttcggacca gacactatgc ccaagcctat tatggctggt ccctgaggca tgctacctat ggcagcggtt tccacttcca tctctacctc atgcacaagg gcgggaagct cagtgtggcc cagctggctc tgggggccca aatcctctca ccccccagac ctcccacctc accttgcttc cttcaggact cagatcatga ggacttcctt agtgccattc agctctga
 OMIM    610145
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ECE2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ECE2. It may not necessarily be applicable to this product.
 NCBI GI #    37588953
 NCBI GeneID    9718
 NCBI Accession #    BC005835 [Other Products]
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 UniProt Secondary Accession #    Q6NTG7; Q6UW36; Q8NFD7; Q96NX3; Q96NX4; Q9BRZ8; A5PLK8 [Other Products]
 UniProt Related Accession #    O60344 [Other Products]
 Molecular Weight    91,211 Da
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 NCBI Official Full Name    Homo sapiens endothelin converting enzyme 2, mRNA
 NCBI Official Synonym Full Names    endothelin converting enzyme 2
 NCBI Official Symbol    ECE2 [Similar Products]
 NCBI Protein Information    endothelin-converting enzyme 2
 UniProt Protein Name    Endothelin-converting enzyme 2
 Protein Family    Endothelin-converting enzyme
 UniProt Gene Name    ECE2 [Similar Products]
 UniProt Synonym Gene Names    KIAA0604; ECE-2 [Similar Products]
 UniProt Entry Name    ECE2_HUMAN
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 NCBI Summary for ECE2    This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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 UniProt Comments for ECE2    ECE2: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; Methyltransferase, protein arginine, predicted; Protease; Vesicle; Membrane protein, integral; EC 3.4.24.71

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: cytoplasmic vesicle membrane

Molecular Function: metalloendopeptidase activity; protein binding

Biological Process: brain development; cardioblast differentiation; cell-cell signaling; heart development; peptide hormone processing
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 Research Articles on ECE2    1. Te results of this study suggested taht genetic variations in MMEL1, ECE1, ECE2, AGER, PLG, PLAT, NR1H3, MMP3, LRP1, TTR, NR1H2, and MMP9 genes do not play major role among the Finnish AD patient cohort.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with ECE2 cdna cloneOrgans/Tissues associated with ECE2 cdna clone
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with ECE2 and Nervous System Diseases
 Arterial Occlusive Diseases Antibodies  >1 publications with ECE2 and Arterial Occlusive Diseases
 Inflammation Antibodies  >1 publications with ECE2 and Inflammation
 Cardiovascular Diseases Antibodies  >1 publications with ECE2 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with ECE2 and Brain
 Muscle Antibodies  >2 publications with ECE2 and Muscle
 Liver Antibodies  >2 publications with ECE2 and Liver
 Ovary Antibodies  >2 publications with ECE2 and Ovary
 Embryonic Tissue Antibodies  >2 publications with ECE2 and Embryonic Tissue
 Adrenal Gland Antibodies  >1 publications with ECE2 and Adrenal Gland
 Lung Antibodies  >1 publications with ECE2 and Lung
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