BC005835
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
91,211 Da
NCBI Official Full Name
Homo sapiens endothelin converting enzyme 2, mRNA
NCBI Official Synonym Full Names
endothelin converting enzyme 2
NCBI Protein Information
endothelin-converting enzyme 2
UniProt Protein Name
Endothelin-converting enzyme 2
UniProt Synonym Gene Names
UniProt Entry Name
ECE2_HUMAN
NCBI Summary for ECE2
This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for ECE2
ECE2: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase; Methyltransferase, protein arginine, predicted; Protease; Vesicle; Membrane protein, integral; EC 3.4.24.71
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: cytoplasmic vesicle membrane
Molecular Function: metalloendopeptidase activity; protein binding
Biological Process: brain development; cardioblast differentiation; cell-cell signaling; heart development; peptide hormone processing
Research Articles on ECE2
1. Te results of this study suggested taht genetic variations in MMEL1, ECE1, ECE2, AGER, PLG, PLAT, NR1H3, MMP3, LRP1, TTR, NR1H2, and MMP9 genes do not play major role among the Finnish AD patient cohort.
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Diseases associated with ECE2 cdna clone
Organs/Tissues associated with ECE2 cdna clone
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