BC011792
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,816 Da
NCBI Official Full Name
Homo sapiens enoyl Coenzyme A hydratase 1, peroxisomal, mRNA
NCBI Official Synonym Full Names
enoyl-CoA hydratase 1
NCBI Official Synonym Symbols
NCBI Protein Information
delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
UniProt Protein Name
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
UniProt Entry Name
ECH1_HUMAN
NCBI Summary for ECH1
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]
UniProt Comments for ECH1
ECH1: Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA. Belongs to the enoyl-CoA hydratase/isomerase family.
Protein type: EC 5.3.3.-; Amino Acid Metabolism - tyrosine; Isomerase; Mitochondrial
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: membrane; mitochondrion
Molecular Function: protein binding; receptor binding
Biological Process: fatty acid catabolic process
Research Articles on ECH1
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Pathways associated with ECH1 cdna clone
Diseases associated with ECH1 cdna clone
Organs/Tissues associated with ECH1 cdna clone
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