BC016464
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102,005 Da
NCBI Official Full Name
Homo sapiens ER degradation enhancer, mannosidase alpha-like 3, mRNA
NCBI Official Synonym Full Names
ER degradation enhancing alpha-mannosidase like protein 3
NCBI Official Synonym Symbols
NCBI Protein Information
ER degradation-enhancing alpha-mannosidase-like protein 3
UniProt Protein Name
ER degradation-enhancing alpha-mannosidase-like protein 3
UniProt Synonym Protein Names
Alpha-1,2-mannosidase EDEM3
UniProt Synonym Gene Names
UniProt Entry Name
EDEM3_HUMAN
NCBI Summary for EDEM3
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]
UniProt Comments for EDEM3
EDEM3: Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity. Belongs to the glycosyl hydrolase 47 family.
Protein type: Hydrolase; EC 3.2.1.113
Chromosomal Location of Human Ortholog: 1q25
Cellular Component: endoplasmic reticulum
Molecular Function: alpha-mannosidase activity; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Biological Process: ER-associated protein catabolic process; N-glycan processing; unfolded protein response
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Pathways associated with EDEM3 cdna clone
Diseases associated with EDEM3 cdna clone
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