BC034393
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,960 Da
NCBI Official Full Name
Homo sapiens endothelin 2, mRNA
NCBI Official Synonym Full Names
endothelin 2
NCBI Protein Information
endothelin-2
UniProt Protein Name
Endothelin-2
UniProt Synonym Protein Names
Preproendothelin-2; PPET2
UniProt Synonym Gene Names
UniProt Entry Name
EDN2_HUMAN
NCBI Summary for EDN2
This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
UniProt Comments for EDN2
EDN2: Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p34
Cellular Component: extracellular region; extracellular space
Molecular Function: endothelin B receptor binding; hormone activity
Biological Process: artery smooth muscle contraction; calcium-mediated signaling; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; elevation of cytosolic calcium ion concentration; hormonal regulation of the force of heart contraction; inositol phosphate-mediated signaling; macrophage activation; macrophage chemotaxis; neutrophil chemotaxis; positive regulation of cell proliferation; positive regulation of heart rate; positive regulation of leukocyte chemotaxis; positive regulation of the force of heart contraction by chemical signal; prostaglandin biosynthetic process; regulation of systemic arterial blood pressure by endothelin; vasoconstriction; vein smooth muscle contraction
Research Articles on EDN2
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Pathways associated with EDN2 cdna clone
Diseases associated with EDN2 cdna clone
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