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EIF4E cdna clone

Scan QR to view Datasheet Catalog #    MBS1266653 EIF4E cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EIF4E, cDNA Clone

★Popular Item★
 Also Known As   

EIF4E cDNA Clone

 Product Gene Name   

EIF4E cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence Positions    1-115. Full length.
 Sequence    atggcgactg tcgaaccgga aaccacccct actcctaatc ccccgactac agaagaggag aaaacggaat ctaatcagga ggttgctaac ccagaacact atattaaaca tcccctacag aacagatggg cactctggtt ttttaaaaat gataaaagca aaacttggca agcaaacctg cggctgatct ccaagtttga tactgttgaa gacttttggg ctctgtacaa ccatatccag ctgtctagta atttaatgcc tggctgtgac tactcacttt ttaaggatgg tattgagcct atgtgggaag atgagaaaaa caaacgggga ggacgatggc taattacatt gaacaaacag cagagacgaa gtgacctcaa tcgcttttgg ctagagacac ttctgtgcct tattggagaa tcttttgatg actacagtga tgatgtatgt ggcgctgttg ttaatgttag agctaaaggt gataagatag caatatggac tactgaatgt gaaaacagag aagctgttac acatataggg agggtataca aggaaaggtt aggacttcct ccaaagatag tgattggtta tcagtcccac gcagacacag ctactaagag cggctccacc actaaaaata ggtttgttgt ttaa
 OMIM    133440
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of EIF4E cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for EIF4E. It may not necessarily be applicable to this product.
 NCBI GI #    15214958
 NCBI GeneID    1977
 NCBI Accession #    BC012611 [Other Products]
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 UniProt Secondary Accession #    Q96E95; B7Z6V1; D6RCQ6 [Other Products]
 UniProt Related Accession #    P06730 [Other Products]
 Molecular Weight    25,097 Da
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 NCBI Official Full Name    Homo sapiens eukaryotic translation initiation factor 4E, mRNA
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 4E
 NCBI Official Symbol    EIF4E [Similar Products]
 NCBI Official Synonym Symbols   
CBP; EIF4F; AUTS19; EIF4E1; eIF-4E; EIF4EL1
[Similar Products]
 NCBI Protein Information    eukaryotic translation initiation factor 4E
 UniProt Protein Name    Eukaryotic translation initiation factor 4E
 UniProt Synonym Protein Names   
eIF-4F 25 kDa subunit; mRNA cap-binding protein
 Protein Family    Eukaryotic translation initiation factor
 UniProt Gene Name    EIF4E [Similar Products]
 UniProt Synonym Gene Names    EIF4EL1; EIF4F; eIF-4E; eIF4E [Similar Products]
 UniProt Entry Name    IF4E_HUMAN
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 NCBI Summary for EIF4E    The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
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 UniProt Comments for EIF4E    EIF4E: a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 4q23

Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 4F complex; mRNA cap complex; perinuclear region of cytoplasm; stress granule

Molecular Function: enzyme binding; eukaryotic initiation factor 4G binding; protein binding; RNA cap binding; translation initiation factor activity

Biological Process: G1/S transition of mitotic cell cycle; mRNA export from nucleus; negative regulation of autophagy; poly(A) tail shortening; positive regulation of mitotic cell cycle; regulation of translation; RNA export from nucleus; translational initiation

Disease: Autism, Susceptibility To, 19
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 Research Articles on EIF4E    1. This review will present eIF4E's structure and functions. It will also expose the use of eIF4E as a therapeutic target in cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with EIF4E cdna cloneDiseases associated with EIF4E cdna clone
 Products by Pathway  Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies  GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >543 publications with EIF4E and Neoplasms
 Carcinoma Antibodies  >185 publications with EIF4E and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >101 publications with EIF4E and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >72 publications with EIF4E and Adenocarcinoma
 Nervous System Diseases Antibodies  >64 publications with EIF4E and Nervous System Diseases
 Hypertrophy Antibodies  >53 publications with EIF4E and Hypertrophy
 Necrosis Antibodies  >48 publications with EIF4E and Necrosis
 Neoplasms, Experimental Antibodies  >46 publications with EIF4E and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >45 publications with EIF4E and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >42 publications with EIF4E and Disease Models, Animal
Organs/Tissues associated with EIF4E cdna clone
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >311 publications with EIF4E and Muscle
 Blood Antibodies  >252 publications with EIF4E and Blood
 Liver Antibodies  >126 publications with EIF4E and Liver
 Brain Antibodies  >117 publications with EIF4E and Brain
 Vascular Antibodies  >103 publications with EIF4E and Vascular
 Heart Antibodies  >87 publications with EIF4E and Heart
 Lung Antibodies  >75 publications with EIF4E and Lung
 Kidney Antibodies  >69 publications with EIF4E and Kidney
 Nerve Antibodies  >41 publications with EIF4E and Nerve
 Pancreas Antibodies  >38 publications with EIF4E and Pancreas
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