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EPHB4 cdna clone

Scan QR to view Datasheet Catalog #    MBS1270720 EPHB4 cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EPHB4, cDNA Clone

 Also Known As   

EPHB4 cDNA Clone

 Product Gene Name   

EPHB4 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    600011
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of EPHB4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for EPHB4. It may not necessarily be applicable to this product.
 NCBI GI #    31127084
 NCBI GeneID    2050
 NCBI Accession #    BC052804 [Other Products]
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 UniProt Secondary Accession #    Q7Z635; Q9BTA5; Q9BXP0; B5A970; B5A971; B5A972 [Other Products]
 UniProt Related Accession #    P54760 [Other Products]
 Molecular Weight    45,195 Da
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 NCBI Official Full Name    Homo sapiens EPH receptor B4, mRNA
 NCBI Official Synonym Full Names    EPH receptor B4
 NCBI Official Symbol    EPHB4 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    ephrin type-B receptor 4
 UniProt Protein Name    Ephrin type-B receptor 4
 UniProt Synonym Protein Names   
Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11
 Protein Family    Ephrin type-B receptor
 UniProt Gene Name    EPHB4 [Similar Products]
 UniProt Synonym Gene Names    HTK; MYK1; TYRO11 [Similar Products]
 UniProt Entry Name    EPHB4_HUMAN
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 NCBI Summary for EPHB4    Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EPHB4    EphB4: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; EC; TK group; Eph family

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: cytosol; extracellular region; integral to plasma membrane; plasma membrane

Molecular Function: ephrin receptor activity; protein binding; transmembrane receptor protein tyrosine kinase activity

Biological Process: angiogenesis; cell adhesion; cell migration during sprouting angiogenesis; ephrin receptor signaling pathway; heart morphogenesis; protein amino acid autophosphorylation
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 Research Articles on EPHB4    1. EphB4 facilitates stromal-mediated support of hematopoiesis in hematopoietic stem cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with EPHB4 cdna cloneDiseases associated with EPHB4 cdna clone
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 EPHB Forward Signaling Pathway antibodies  EPHB Forward Signaling Pathway Diagram
 Ephrin B Reverse Signaling Pathway antibodies  Ephrin B Reverse Signaling Pathway Diagram
 EphrinB-EPHB Pathway antibodies  EphrinB-EPHB Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >122 publications with EPHB4 and Neoplasms
 Breast Neoplasms Antibodies  >18 publications with EPHB4 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >17 publications with EPHB4 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >16 publications with EPHB4 and Lung Neoplasms
 Lung Diseases Antibodies  >15 publications with EPHB4 and Lung Diseases
 Adenocarcinoma Antibodies  >12 publications with EPHB4 and Adenocarcinoma
 Brain Diseases Antibodies  >11 publications with EPHB4 and Brain Diseases
 Inflammation Antibodies  >10 publications with EPHB4 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >7 publications with EPHB4 and Carcinoma, Hepatocellular
 Uterine Neoplasms Antibodies  >7 publications with EPHB4 and Uterine Neoplasms
Organs/Tissues associated with EPHB4 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >141 publications with EPHB4 and Vascular
 Embryonic Tissue Antibodies  >50 publications with EPHB4 and Embryonic Tissue
 Bone Antibodies  >37 publications with EPHB4 and Bone
 Brain Antibodies  >35 publications with EPHB4 and Brain
 Lung Antibodies  >31 publications with EPHB4 and Lung
 Eye Antibodies  >24 publications with EPHB4 and Eye
 Muscle Antibodies  >23 publications with EPHB4 and Muscle
 Heart Antibodies  >20 publications with EPHB4 and Heart
 Nerve Antibodies  >12 publications with EPHB4 and Nerve
 Liver Antibodies  >12 publications with EPHB4 and Liver
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