BC110404
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,066 Da
NCBI Official Full Name
Homo sapiens fatty acid amide hydrolase, mRNA
NCBI Official Synonym Full Names
fatty acid amide hydrolase
NCBI Official Synonym Symbols
NCBI Protein Information
fatty-acid amide hydrolase 1
UniProt Protein Name
Fatty-acid amide hydrolase 1
UniProt Synonym Protein Names
Anandamide amidohydrolase 1; Oleamide hydrolase 1
UniProt Synonym Gene Names
UniProt Entry Name
FAAH1_HUMAN
NCBI Summary for FAAH
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
UniProt Comments for FAAH
FAAH: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Homodimer. Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. Inhibited by O-aryl carbamates and alpha-keto heterocytes. Belongs to the amidase family.
Protein type: Membrane protein, integral; EC 3.5.1.99; Hydrolase
Chromosomal Location of Human Ortholog: 1p35-p34
Cellular Component: endoplasmic reticulum membrane
Molecular Function: fatty acid amide hydrolase activity; protein binding
Biological Process: arachidonic acid metabolic process; fatty acid catabolic process
Disease: Polysubstance Abuse, Susceptibility To
Research Articles on FAAH
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Pathways associated with FAAH cdna clone
Diseases associated with FAAH cdna clone
Organs/Tissues associated with FAAH cdna clone
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