BC069466
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,207 Da
NCBI Official Full Name
Homo sapiens fatty acid binding protein 2, intestinal, mRNA
NCBI Official Synonym Full Names
fatty acid binding protein 2
NCBI Protein Information
fatty acid-binding protein, intestinal
UniProt Protein Name
Fatty acid-binding protein, intestinal
UniProt Synonym Protein Names
Fatty acid-binding protein 2; Intestinal-type fatty acid-binding protein; I-FABP
UniProt Synonym Gene Names
UniProt Entry Name
FABPI_HUMAN
NCBI Summary for FABP2
The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008]
UniProt Comments for FABP2
FABP2: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Protein type: Transporter; Lipid-binding
Chromosomal Location of Human Ortholog: 4q28-q31
Cellular Component: cytosol
Molecular Function: protein binding
Biological Process: digestion; triacylglycerol catabolic process
Research Articles on FABP2
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Pathways associated with FABP2 cdna clone
Diseases associated with FABP2 cdna clone
Organs/Tissues associated with FABP2 cdna clone
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