BC007846
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,474 Da
NCBI Official Full Name
Homo sapiens fatty acid desaturase 1, mRNA
NCBI Official Synonym Full Names
fatty acid desaturase 1
NCBI Official Synonym Symbols
D5D; TU12; FADS6; FADSD5; LLCDL1 [Similar Products]
NCBI Protein Information
fatty acid desaturase 1
UniProt Protein Name
Fatty acid desaturase 1
UniProt Synonym Protein Names
Delta(5) fatty acid desaturase; D5D; Delta(5) desaturase; Delta-5 desaturase
UniProt Synonym Gene Names
UniProt Entry Name
FADS1_HUMAN
NCBI Summary for FADS1
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
UniProt Comments for FADS1
FADS1: Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3) respectively. Belongs to the fatty acid desaturase family.
Protein type: Lipid Metabolism - unsaturated fatty acid biosynthesis; EC 1.14.19.-; Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q12.2-q13.1
Cellular Component: endoplasmic reticulum membrane; membrane
Molecular Function: C-5 sterol desaturase activity; omega-6 fatty acid desaturase activity; oxidoreductase activity
Biological Process: cellular response to starvation; icosanoid biosynthetic process; linoleic acid metabolic process; phospholipid biosynthetic process; unsaturated fatty acid biosynthetic process
Research Articles on FADS1
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Pathways associated with FADS1 cdna clone
Diseases associated with FADS1 cdna clone
Organs/Tissues associated with FADS1 cdna clone
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