BC005894
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,644 Da
NCBI Official Full Name
Homo sapiens flavin containing monooxygenase 2 (non-functional), mRNA
NCBI Official Synonym Full Names
flavin containing monooxygenase 2
NCBI Official Synonym Symbols
NCBI Protein Information
dimethylaniline monooxygenase [N-oxide-forming] 2
UniProt Protein Name
Dimethylaniline monooxygenase [N-oxide-forming] 2
UniProt Synonym Protein Names
Dimethylaniline oxidase 2; FMO 1B1; Pulmonary flavin-containing monooxygenase 2; FMO 2
UniProt Synonym Gene Names
UniProt Entry Name
FMO2_HUMAN
NCBI Summary for FMO2
This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
UniProt Comments for FMO2
Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.
Research Articles on FMO2
Precautions
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Disclaimer
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Pathways associated with FMO2 cdna clone
Diseases associated with FMO2 cdna clone
Organs/Tissues associated with FMO2 cdna clone
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