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FOXP2 cdna clone

Scan QR to view Datasheet Catalog #    MBS1274981 FOXP2 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FOXP2, cDNA Clone

★Popular Item★
 Also Known As   

FOXP2 cDNA Clone

 Product Gene Name   

FOXP2 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgatgcagg aatctgcgac agagacaata agcaacagtt caatgaatca aaatggaatg agcactctaa gcagccaatt agatgctggc agcagagatg gaagatcaag tggtgacacc agctctgaag taagcacagt agaactgctg catctgcaac aacagcagga ggatgttgtc tcttacaccc aggttatttg ttaa
 Chromosome Location    Chromosome: 7; NC_000007.13 (113726365..114333827). Location: 7q31
 OMIM    602081
 3D Structure    ModBase 3D Structure for O15409
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of FOXP2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for FOXP2. It may not necessarily be applicable to this product.
 NCBI GI #    17390020
 NCBI GeneID    93986
 NCBI Accession #    BC018016 [Other Products]
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 UniProt Primary Accession #    O15409 [Other Products]
 UniProt Secondary Accession #    Q6ZND1; Q75MJ3; Q8IZE0; Q8N0W2; Q8N6B7; Q8N6B8; Q8NFQ1; A0AUV6; A4D0U8; A6NNW4; B4DLD9 [Other Products]
 UniProt Related Accession #    O15409 [Other Products]
 Molecular Weight    79,919 Da
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 NCBI Official Full Name    Homo sapiens forkhead box P2, mRNA
 NCBI Official Synonym Full Names    forkhead box P2
 NCBI Official Symbol    FOXP2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    forkhead box protein P2; CAG repeat protein 44; trinucleotide repeat containing 10; forkhead/winged-helix transcription factor; trinucleotide repeat-containing gene 10 protein
 UniProt Protein Name    Forkhead box protein P2
 UniProt Synonym Protein Names   
CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein
 Protein Family    Forkhead box protein
 UniProt Gene Name    FOXP2 [Similar Products]
 UniProt Synonym Gene Names    CAGH44; TNRC10 [Similar Products]
 UniProt Entry Name    FOXP2_HUMAN
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 NCBI Summary for FOXP2    This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
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 UniProt Comments for FOXP2    FOXP2: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; metal ion binding; transcription factor activity

Biological Process: caudate nucleus development; skeletal muscle development; camera-type eye development; transcription, DNA-dependent; righting reflex; putamen development; negative regulation of transcription from RNA polymerase II promoter; vocal learning; post-embryonic development; smooth muscle development; positive regulation of mesenchymal cell proliferation; cerebellum development; cerebral cortex development; negative regulation of transcription, DNA-dependent; alveolus development; growth

Disease: Speech-language Disorder 1
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 Research Articles on FOXP2    1. Our data do not support the previous hypothesis that the parental origin of FOXP2 alterations could influence the severity of speech impairment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with FOXP2 cdna cloneOrgans/Tissues associated with FOXP2 cdna clone
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >99 publications with FOXP2 and Nervous System Diseases
 Neurobehavioral Manifestations Antibodies  >93 publications with FOXP2 and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >30 publications with FOXP2 and Learning Disorders
 Brain Diseases Antibodies  >19 publications with FOXP2 and Brain Diseases
 Autistic Disorder Antibodies  >19 publications with FOXP2 and Autistic Disorder
 Cognition Disorders Antibodies  >15 publications with FOXP2 and Cognition Disorders
 SPEECH-LANGUAGE DISORDER 1 Antibodies  >12 publications with FOXP2 and SPEECH-LANGUAGE DISORDER 1
 Apraxias Antibodies  >12 publications with FOXP2 and Apraxias
 Congenital Abnormalities Antibodies  >11 publications with FOXP2 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >8 publications with FOXP2 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >138 publications with FOXP2 and Brain
 Nerve Antibodies  >37 publications with FOXP2 and Nerve
 Lung Antibodies  >17 publications with FOXP2 and Lung
 Embryonic Tissue Antibodies  >13 publications with FOXP2 and Embryonic Tissue
 Eye Antibodies  >8 publications with FOXP2 and Eye
 Bone Antibodies  >5 publications with FOXP2 and Bone
 Intestine Antibodies  >3 publications with FOXP2 and Intestine
 Skin Antibodies  >3 publications with FOXP2 and Skin
 Thyroid Antibodies  >3 publications with FOXP2 and Thyroid
 Muscle Antibodies  >3 publications with FOXP2 and Muscle
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