BC113466
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,818 Da
NCBI Official Full Name
Homo sapiens growth arrest and DNA-damage-inducible, beta, mRNA
NCBI Official Synonym Full Names
growth arrest and DNA damage inducible beta
NCBI Protein Information
growth arrest and DNA damage-inducible protein GADD45 beta
UniProt Protein Name
Growth arrest and DNA damage-inducible protein GADD45 beta
UniProt Synonym Protein Names
Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118
UniProt Synonym Gene Names
UniProt Entry Name
GA45B_HUMAN
NCBI Summary for GADD45B
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
UniProt Comments for GADD45B
GADD45B: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Belongs to the GADD45 family.
Protein type: Apoptosis; Cell development/differentiation
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding
Biological Process: activation of MAPKKK activity; positive regulation of apoptosis; positive regulation of JNK cascade
Research Articles on GADD45B
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with GADD45B cdna clone
Diseases associated with GADD45B cdna clone
Organs/Tissues associated with GADD45B cdna clone
|